36368-44-2

Basic information

• Product Name: (6-oxabicyclo[3.1.0]hexan-3-yl)methanol
• Synonyms: (6-oxabicyclo[3.1.0]hexan-3-yl)methanol
• CAS NO: 36368-44-2
• Molecular Weight: 114.144
• Mol File: 36368-44-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (6-oxabicyclo[3.1.0]hexan-3-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (6-oxabicyclo[3.1.0]hexan-3-yl)methanol(36368-44-2)
• EPA Substance Registry System: (6-oxabicyclo[3.1.0]hexan-3-yl)methanol(36368-44-2)

Safety Data

• Hazardous Substances Data: 36368-44-2(Hazardous Substances Data)

Upstream product

• 25125-21-7 4-(hydroxymethyl)cyclopentene 
• 58101-60-3 methyl cyclopent-3-ene-1-carboxylate 

Relevant articles and documents

THERAPEUTIC METHODS

The invention provides methods and compositions for delivering a nucleic acid to a cell or the cytosol of the target cell. The method includes contacting the cell with, 1) a membrane-destabilizing polymer; and 2) a nucleic acid conjugate. The nucleic acid conjugate includes a targeting ligand bound to an optional linker and a nucleic acid.

TARGETED COMPOSITIONS

The invention provides certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups. Certain embodiments also provide synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic double stranded siRNA to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).

Cyclit-Reaktionen, II. Darstellung von Bausteinen zur Synthese carbocyclischer Furanose-Analoga

The four isomeric hydroxycyclopentenmethanols 6a to 9a can easily be made by allylhydroxylation of the epoxides 2 and 4 with phenyl selenide.In a second way the pair 8a and 9a has been synthesized from 11 via 15.As the preparation of 20 demonstrates, the functionalisation of 6a to 9a to carbocyclic furanoses is possible.The dicarboxylic diethyl esters 23 and 33 can be converted into models for carbocyclic ketofuranoses.