364-75-0

Basic information

• Product Name: 2-Fluoro-5-iodonitrobenzene
• Synonyms: 2-Fluoro-5-iodonitrobenzene;4-Iodo-2-nitrofluorobenzene;1-fluoro-4-iodo-2-nitrobenzene;2-Fluoro-5-iodonitrobenzene 97%;2-Fluoro-5-iodonitrobenzene97%
• CAS NO: 364-75-0
• Molecular Formula: C₆H₃FINO₂
• Molecular Weight: 266.9963932
• Mol File: 364-75-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 289.362°C at 760 mmHg
• Flash Point: 128.802°C
• Appearance: /
• Density: 2.093g/cm³
• Vapor Pressure: 0.004mmHg at 25°C
• Refractive Index: 1.635
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 2-Fluoro-5-iodonitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-5-iodonitrobenzene(364-75-0)
• EPA Substance Registry System: 2-Fluoro-5-iodonitrobenzene(364-75-0)

Safety Data

• Hazardous Substances Data: 364-75-0(Hazardous Substances Data)

Usage

General Description

2-Fluoro-5-iodonitrobenzene is a chemical compound consisting of a benzene ring with a fluorine atom in the 2-position and an iodine atom in the 5-position, as well as a nitro group. It is commonly used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and organic compounds. The presence of both the fluoro and iodo groups makes this compound useful in the development of new molecules for medicinal and material science applications. It is important to handle this compound with care, as it is potentially hazardous and should only be used by trained professionals in a controlled laboratory environment.

InChI:InChI=1/C6H3FINO2/c7-5-2-1-4(8)3-6(5)9(10)11/h1-3H

Upstream product

• 352-34-1 4-fluoro-1-iodobenzene 
• 364-76-1 4-Fluoro-3-nitroaniline 
• 1493-27-2 ortho-nitrofluorobenzene 
• 1000339-51-4 3-fluoro-2-nitro-benzoic acid 

Downstream Products

• 52692-09-8 4-iodo-2-nitroanisole 
• 20691-72-9 4-iodo-2-nitroaniline 
• 79291-47-7 3-(4-Iodo-2-nitroanilino)-1-methylpyrazole-4-carbonitrile 
• 769159-85-5 4-cyclopropyl-1-fluoro-2-nitrobenzene 
• 594862-23-4 N-benzyl-4-iodo-2-nitroaniline 
• 866686-98-8 3-chloro-5-(4-fluoro-3-nitrophenylethynyl)-pyridine 
• 1080522-04-8 ethyl 2-(4-(4-iodo-2-nitrophenoxy)-3-methoxyphenyl)acetate 
• 1160926-61-3 1-(4-iodo-2-nitrophenyl)-4-phenyl-1H-1,2,3-triazole 
• 1246566-57-3 1-dodecylthio-4-iodo-2-nitrobenzene 
• 1430727-54-0 N-(5-(2-amino-4-iodophenylamino)-2',4'-difluorobiphenyl-3-yl)acetamide 
• 1430727-56-2 N-(2',4'-difluoro-5-(5-iodo-1H-benzo[d]imidazol-1-yl)biphenyl-3-yl)acetamide 
• 1430727-57-3 N-(2',4'-difluoro-5-(5-((trimethylsilyl)ethynyl)-1H-benzo[d]imidazol-1-yl)-biphenyl-3-yl)acetamide 
• 1430727-59-5 N-(5-(5-ethynyl-1H-benzo[d]imidazol-1-yl)-2',4'-difluorobiphenyl-3-yl)-acetamide 
• 1430723-47-9 N-(2',4'-difluoro-5-(5-(1-methyl-1H-1,2,3-triazol-4-yl)-1H-benzo[d]imidazol-1-yl)biphenyl-3-yl)acetamide 

Relevant articles and documents

Pd-Catalyzed Decarboxylative Ortho-Halogenation of Aryl Carboxylic Acids with Sodium Halide NaX Using Carboxyl as a Traceless Directing Group

A highly regioselective Pd-catalyzed carboxyl directed decarboxylative ortho-C-H halogenation of cheap o-nitrobenzoic acids with NaX (X = I, Br) under aerobic conditions has been established. The utility of the method has been demonstrated by the gram-scale reaction and derivatization of the product. Experimental results have confirmed Pd and Bi played critical roles in the transformation and indicated the transformation might proceed via 2-halo-6-nitrobenzoic acid derivative intermediate.

PROTEIN KINASE INHIBITORS

A compound of formula (I), wherein R3, R4, G, B, M, and Z are as defined in the claims, and pharmaceutically acceptable salts thereof are disclosed. The compounds of formula (I) possess utility as FGFR inhibitors and are useful in the treatment of a condition, where FGFR kinase inhibition is desired, such as cancer.

PYRIDYL DERIVATIVES AND THEIR USE AS MGLU5 RECEPTOR ANTAGONISTS

The present invention is directed toward pyridyl derivatives of formula (I) as antagonists of the mGlu5 receptor. As such the compounds may be useful for treatment or prevention of disorders remedied by antagonism of the mGlu5 receptor, wherein Ar is phenyl or napthyl each of which may be substituted by one or more C1-C4 alkyl, C1-C4 alkoxy, C1-C5 acyl, halo, amino, nitro, cyano, hydroxy, C1-C5 acylamino, C1-C4 alkylsulfonylamino, mono-, di- or trifluorinated C1-C3 alkyl, substituents which may be the same or different and may bear a CONH2, CONHCH3, CON(CH3)2, CO2H, CO2CH3, OCF3, CH2NHCOCH3, CH2NH2, CH2N(CH3)2, CH2CN, CH2OH, CH2NHSO2CH3, CH2N(CH3)(CH2)2 CN, CH2N(CH3)CH(CH3)2, CH2NHCH(CH3)2, CH2NH(CH2)2CH3, CH2NHCO2R4, CH2NHCH2CH3, CH2NHCH3 NHCOC(CH3)2, or N(S(O)2CH3)2 substituent; R1 is hydrogen, halo, R4, CN, C(NOH)R3, C(NO-R4)R3, (CH)2CO2R4 , (CH2)n OR3 , COR3 , CF3,SR4 , S(O)R4, S(O)2R4, COCH2CO2R3 , NHSO2R4 , NHCOR3, C(NOR3)NH2, CH2OCOR3,(CH2)n NH2, CON(CH3)2 (CH2)nNHCO2R4 , CO2R3, CONH2, CSNH2, C(NH)NHOR3, (CH2)nN(CH3)2, or CONHNHCOR3; R2 is 1,2-ethenediyl or 1,2-ethynediyl; R3 is hydrogen or C1-C4 alkyl; R4 is C1-C4 alkyl; and n is 0, 1, 2,3 or 4; or a pharmaceutically acceptable salt thereof, or an N-oxide thereof.