364-83-0

Basic information

• Product Name: 2',4'-Difluoroacetophenone
• Synonyms: Acetophenone, 2',4'-difluoro-;2',4'-DIFLUOROACETOPHENONE;2,4-DIFLUOROACETOPHENONE;1-(2,4-DIFLUOROPHENYL)ETHANONE;1-(2,4-difluorophenyl)ethan-1-one;2',4'-Difluoroacetophenone 1-(2,4-Difluorophenyl)ethan-1-one;2,4-Difluoroacetophenone,98%;2',4'-Difluoroacetophenone 98%
• CAS NO: 364-83-0
• Molecular Formula: C₈H₆F₂O
• Molecular Weight: 156.13
• EINECS: 206-667-6
• Product Categories: Other fluorin-contained compounds;Acetophenone Series;Aromatic Acetophenones & Derivatives (substituted);Fluorobenzene;ketone;Adehydes, Acetals & Ketones;Fluorine Compounds;C7 to C8;Carbonyl Compounds;Ketones
• Mol File: 364-83-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 80-81 °C25 mm Hg(lit.)
• Flash Point: 152 °F
• Appearance: Clear colorless to yellow/Liquid
• Density: 1.234 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.488(lit.)
• Storage Temp.: Store below +30°C.
• Water Solubility: INSOLUBLE
• BRN: 1940741
• CAS DataBase Reference: 2',4'-Difluoroacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2',4'-Difluoroacetophenone(364-83-0)
• EPA Substance Registry System: 2',4'-Difluoroacetophenone(364-83-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• F: 8
• TSCA: T
• HazardClass: IRRITANT
• Hazardous Substances Data: 364-83-0(Hazardous Substances Data)

Usage

Description

2',4'-Difluoroacetophenone is a clear colorless to yellow liquid with a distinct chemical structure, featuring two fluorine atoms at the 2' and 4' positions of the acetophenone molecule. It has been the subject of vibrational spectral analysis through FT-IR and FT-Raman spectroscopy, providing insights into its chemical properties.

Uses

Used in Pharmaceutical Industry:
2',4'-Difluoroacetophenone is used as a starting reagent for the synthesis of difluorinated chalcones, which are important intermediates in the development of various pharmaceutical compounds. These chalcones have potential applications in the treatment of different diseases due to their unique chemical properties and biological activities.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2',4'-Difluoroacetophenone serves as a valuable building block for creating a range of fluorinated organic compounds. The presence of fluorine atoms in its structure can significantly influence the reactivity, stability, and biological activity of the resulting molecules, making it a versatile starting material for various synthetic applications.

Upstream product

• 372-18-9 1,3-Difluorobenzene 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 
• 348-57-2 2,4-difluorobromobenzene 
• 75-05-8 acetonitrile 
• 13918-92-8 2,4-difluorobenzene-1-sulfonyl chloride 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 51336-94-8 2-chloro-1-(2,4-dichlorophenyl)ethanone 

Downstream Products

• 2267-47-2 1-(2,4-difluorophenyl)ethan-1-ol 
• 98556-24-2 2,2-dibromo-1-(2,4-difluoro-phenyl)-ethanone 
• 150555-91-2 4-fluoro-2-(phenylmethylthio)benzaldehyde 
• 150555-92-3 1-(2-(benzylthio)-4-fluorophenyl)ethan-1-one 
• 142472-18-2 1,3-di-(2,4-difluorophenyl)-1,3-propanedione 
• 79784-36-4 2-(2,4-difluorophenyl)-2-oxoacetaldehyde 
• 179011-35-9 2,4-difluoro-5-nitroacetophenone 
• 64287-17-8 1-(2,4-Difluoro-phenyl)-butane-1,3-dione 
• 102429-07-2 2-bromo-2',4'-difluoroacetophenone 
• 219488-04-7 RL₃₉₉ 
• 175846-98-7 N-<1-(2,4-difluorophenyl)ethylidene>-2-(trifluoromethyl)aniline 
• 220996-60-1 2-(2,2,2-trifluoroethoxy)-4-fluoroacetophenone 

Relevant articles and documents

Promoting charge separation in donor-acceptor conjugated microporous polymers: Via cyanation for the photocatalytic reductive dehalogenation of chlorides

Conjugated microporous polymers (CMPs) have emerged as promising heterogeneous photocatalysts for organic transformations owing to their structural designability and functional versatility. However, limited by the insufficient separation of the photo-generated excitons, their photocatalytic efficiency falls far short of expectations. Herein, we demonstrate a cyanation strategy to promote charge carrier separation in CMPs by selectively incorporating carbazole and cyano groups as electron-donating and electron-withdrawing units, respectively. The resulting CMPs feature π-extended donor (D)-acceptor (A) conjugation structures endowing them with distinct semiconducting properties, in which the efficient charge separation and transfer and wide visible-light absorption are facilitated. Compared to the cyano-free counterpart, the cyano-functionalized CMPs showed superior photocatalytic efficiency as exemplified by photocatalytic reductive dehalogenation of chlorides. More prominently, full recyclability of the designed CMPs as well as catalytic activity for at least ten runs without the loss of catalytic performance in photocatalytic reductive dehalogenation of chlorides demonstrated their robustness and sustainability. This journal is

Synthesis of 2-fluorocholine aryl carbonyl compounds

The invention provides a method for synthesizing 2-fluoroarylcarbonyl compounds, which comprises the following steps: converting arylcarbonyl compounds into corresponding carbonyl oxime ether compounds, mildly implementing aryl hydrocarbon chain direct fluoridation of high-selectivity oximido substituent group ortho-position in the presence of a palladium catalyst, a fluoridation reagent and additives, and finally, rehydrolyzing oxime ethers under the action of acid to obtain the 2-fluoroarylcarbonyl compounds. The fluoridation method has the advantages of mild reaction conditions, high substrate adaptability, high fluoridation selectivity and the like, is simple to operate, and has higher application research value.

SAR, cardiac myocytes protection activity and 3D-QSAR studies of salubrinal and its potent derivatives

Salubrinal is a selective inhibitor of endoplasmic reticulum (ER) stress and affords remarkable protection to cardiomyocytes. By studying the structure-activity relationship (SAR) of salubrinal, it was found that modification of the quinoline ring terminus and thiourea unit could confer the compound PP1-24 with markedly enhanced cardioprotective activity (EC 50 2 = 0.741, r2 = 0.991).