36401-58-8

Basic information

• Product Name: 2H-1,2,3-Triazole-4-carboxylic acid, 2,5-diphenyl-
• CAS NO: 36401-58-8
• Molecular Formula: C15H11N3O2
• Molecular Weight: 265.271
• Mol File: 36401-58-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2H-1,2,3-Triazole-4-carboxylic acid, 2,5-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1,2,3-Triazole-4-carboxylic acid, 2,5-diphenyl-(36401-58-8)
• EPA Substance Registry System: 2H-1,2,3-Triazole-4-carboxylic acid, 2,5-diphenyl-(36401-58-8)

Safety Data

• Hazardous Substances Data: 36401-58-8(Hazardous Substances Data)

Usage

General Description

2H-1,2,3-Triazole-4-carboxylic acid, 2,5-diphenyl- is a chemical compound that belongs to the triazole family. It is characterized by a 2,5-diphenyl substitution on the triazole ring, and a carboxylic acid functional group at position 4. 2H-1,2,3-Triazole-4-carboxylic acid, 2,5-diphenyl- has potential applications in medicinal chemistry and drug development, particularly in the synthesis of pharmaceuticals and bioactive compounds. Its unique structure and reactivity make it a valuable building block for the construction of diverse molecular scaffolds, and it may exhibit interesting biological activities that could be further explored for therapeutic purposes.

Upstream product

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• 91816-23-8 3-Phenyl-4-(phenyl-hydrazono)-4H-isoxazole-5-thione 
• 4865-99-0 4-phenylhydrazono-3-phenyl-2-isoxazolin-5-one 
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• 74099-22-2 2,5-diphenyl-1,2,3-triazole-4-methylthiocarboxylate 
• 154109-98-5 C₁₅H₁₀ClN₃O 
• 112630-37-2 2,5-Diphenyl-2H-1,2,3-triazol-4-carbonsaeuremethylester 
• 858000-79-0 4-methyl-2,5-diphenyl-2H-[1,2,3]triazole 
• 77169-05-2 4,4-dibromo-1,3-diphenyl-2-pyrazolin-5-one 
• 148637-95-0 (E)-2-Chloro-3-phenyl-3-phenylazo-acrylamide 
• 77169-08-5 4,4-diazido-1,3-diphenyl-1H-pyrazol-5(4H)-one 

Relevant articles and documents

The specific binding of a new 1,2,3-triazole to three blood proteins and it's appended rhodamine complex for selective detection of Hg2+

A synthesized compound, ethyl 2,5-diphenyl-2H-1,2,3-triazole-4- carboxylate (EDTC) was investigated on its physiochemical parameters and structural properties by using the quantum-chemical method. The results on the theoretical spectrum of EDTC were line with experimental fluorescence and absorption spectrum in large degree. Then EDTC was successfully synthesized to a novel rhodamine-based fluorescent probe (REDTC), which showed a distinct fluorescence enhancement upon the presence of Hg2+ in dimethyl formamide-water (DMF-H2O) buffer solution (pH 7.4). Meanwhile, the triazole appended colorless compound turns to pink upon complex formation with Hg2+ ions as 1:2 molar ratios and enables naked-eye detection. The chromogenic mechanism was determined by using spectroscopic measurements and TD DFT calculation. The fluorescence imaging experiments of Hg2+ in HeLa cell revealed that the probe REDTC could be labeled and it could be used in biological systems. Also, the intermediate EDTC was developed as a sensitive fluorescent probe for specific studies on the interactions to three kinds of blood proteins including human serum albumin (HSA), human immunoglobulin (HIg) and bovine hemoglobin (BHb) by using a series of spectroscopic methods and molecular docking under the simulative physiological conditions. The interactions between EDTC and these proteins led to the distinct fluorescence enhancement. The thermodynamic measured results further suggested that hydrophobic forces play a dominating role in stabilizing the complexes, which are in correspondence with the results from molecular docking. The UV–visible, synchronous, and three-dimensional (3D) fluorescence measurements demonstrated that EDTC influences the conformational of proteins and the microenvironment surrounding HSA, HIg, or BHb in aqueous solution.

1-Arylimino-pyrazole Betaines, Pyrazoles and 1,2,4-Triazines from 3-Arylazo-propenoic Acid N-Chloroamides

Reaction of 3-arylazo-propenoic acid amides 5 with NaOCl yields N-chloroamides 6 which give under alkaline conditions 1,2,4-triazines 9 and 10 (products of a Hofmann degradation).This reaction competes with an intramolecular electrophilic amination and a

Studies on Arylhydrazonoisoxazolinethiones. Behaviour of 4-Arylhydrazono-3-phenyl-2-isoxazoline-5-thiones Toward Hydrazines, Grignard Reagents and Alkylating Agents

The 4-arylhydrazono-3-phenyl-2-isoxazoline-5-thiones 2 react with hydrazines to yield the 5-hydrazones 3 and 5.The reaction of 2 with Grignard reagent resulted in addition of the reagent to the thiocarbonyl group to yield 7.Treatment of 2 with diazomethan