36421-15-5 Usage
Description
N-(3-chloropropyl)dibutylamine is an organic compound with the chemical formula C13H28ClN. It is a colorless liquid at room temperature and has a molecular weight of approximately 233.83 g/mol. N-(3-chloropropyl)dibutylamine is characterized by the presence of a chloropropyl group attached to a nitrogen atom, which is connected to two butyl groups. Its unique structure makes it a versatile reagent in various chemical processes.
Uses
Used in Pharmaceutical Industry:
N-(3-chloropropyl)dibutylamine is used as a reagent in the synthesis of dronedarone hydrochloride, an antiarrhythmia drug. It plays a crucial role in the production process, contributing to the development of this medication that helps regulate abnormal heart rhythms and prevent complications associated with arrhythmias.
Additionally, N-(3-chloropropyl)dibutylamine is also used as an impurity in butoprozine, another antiarrhythmic drug. The presence of this compound in butoprozine is essential for the drug's efficacy and safety, as it helps maintain the desired pharmacological properties and minimizes potential side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 36421-15-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,4,2 and 1 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 36421-15:
(7*3)+(6*6)+(5*4)+(4*2)+(3*1)+(2*1)+(1*5)=95
95 % 10 = 5
So 36421-15-5 is a valid CAS Registry Number.
InChI:InChI=1/C11H24ClN/c1-3-5-9-13(10-6-4-2)11-7-8-12/h3-11H2,1-2H3
36421-15-5Relevant articles and documents
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Blicke,Otsuki
, p. 2435 (1941)
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Convergent synthesis of dronedarone, an antiarrhythmic agent
Okitsu, Takashi,Ogasahara, Mizuki,Wada, Akimori
, p. 1149 - 1153 (2016/08/11)
We have developed a convergent synthesis of dronedarone, an antiarrhythmic agent. The key steps of the process are the construction of a benzofuran skeleton by iodocyclization and the carbonylative Suzuki-Miyaura cross-coupling for biaryl ketone formation. This synthetic route required only eight steps from 2-amino-4-nitrophenol in 23% overall yield.
PROCESS FOR PREPARING BENZOFURAN DERIVATIVES SUBSTITUTED AT POSITION 5
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Paragraph 0116, (2013/07/05)
The disclosure relates to a process for preparing benzofuran derivatives of general formula I: in which R, R1, and R2 are as defined in the disclosure; by coupling the hydroxylamine with a diketone of general formula III: in order to form an oxime that is then cyclized by heating in order to form the desired compound.