364634-52-6

Basic information

• Product Name: pentanedioic acid 2-(2-amino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-ethyl ester benzyl ester
• Synonyms: pentanedioic acid 2-(2-amino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-ethyl ester benzyl ester
• CAS NO: 364634-52-6
• Molecular Weight: 429.433
• Mol File: 364634-52-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: pentanedioic acid 2-(2-amino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-ethyl ester benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: pentanedioic acid 2-(2-amino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-ethyl ester benzyl ester(364634-52-6)
• EPA Substance Registry System: pentanedioic acid 2-(2-amino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-ethyl ester benzyl ester(364634-52-6)

Safety Data

• Hazardous Substances Data: 364634-52-6(Hazardous Substances Data)

Upstream product

• 59277-89-3 acycloguanosine 
• 54322-10-0 glutaric acid monobenzyl ester 
• 364634-35-5 9-(2-trimethylsilyloxyethoxymethyl)guanine 
• 100-51-6 benzyl alcohol 
• 75128-73-3 2-acetylamino-9-(2-acetoxyethoxymethyl)purine-6-one 
• 73-40-5 2-amino-1,9-dihydro-6H-purin-6-one 
• 108-55-4 glutaric anhydride, 

Relevant articles and documents

Regioselective synthesis of acyclovir and its various prodrugs

High-yield regioselective synthesis of 9-[(2-hydroxyethoxy)methyl]guanine (Acyclovir 1, Scheme 1) was achieved from guanine via trisilylated guanine. N2-acylacyclovir 9a-9b were prepared from N2, O-diacylacyclovir (4, 8b-8d) using regioselective deacylation procedure. N2-Acylacyclovir 11 and 13 were prepared via protection of primary hydroxyl groups. Three amino acid esters of acyclovir were synthesized as water-soluble prodrugs, which form protonated cations in pH 7.4 phosphate buffer. Two water-soluble ester prodrugs with free carboxylic acids, which form anionic species in pH 7.4 phosphate buffer, were also synthesized.