36508-71-1 Usage
Description
Zorubicin Hydrochloride, also known as Rubidazone, is an anthracycline anti-cancer drug closely related to Daunorubicin. It is a synthetic compound derived from the Streptomyces peucetius var. caesius bacteria and exhibits a unique chemical structure that contributes to its anti-cancer properties. Zorubicin HCL intercalates DNA, inhibiting topoisomerase II and leading to the prevention of DNA replication and transcription. This action results in the disruption of cancer cell division and ultimately the death of these cells.
Uses
Used in Antineoplastic Applications:
Zorubicin HCL is used as an antineoplastic agent for the treatment of various types of cancer. It is particularly effective against solid malignancies, including liver, breast, lung, pancreatic, colorectal, and ovarian cancers. The drug modulates several oncological signaling pathways, exerting inhibitory effects on tumor growth and progression.
Used in Pharmaceutical Industry:
Zorubicin HCL is used as an active pharmaceutical ingredient in the development of cancer therapeutics. Its unique mechanism of action and effectiveness against a range of malignancies make it a valuable component in the creation of life-saving medications for cancer patients.
Originator
Zorubicin
Hydrochloride,ZYF Pharm
Chemical
Manufacturing Process
9.024 g daunorubicin-hydrochloride (its preparation and physicochemical
properties have been described in British Patent Specification No 985 598)
was dissolved in 800 ml ethanol and mixed with 2.5 ml acetic acid and 2.162
g benzoyl hydrazide and heated for 24 hours at 60°C. On cooling the obtained
precipitate was filtered off, washed with 100 ml of ethanol and dried in
vacuum at 20°C. It was dissolved in water and small quantity of insoluble
product was filtered off, the filtrate was lyophilized. (1-(4-((3-Amino-2,3,6-
trideoxy-α,L-lyxohexopyranosyl)oxy)-1,2,3,4,6,11-hexahydro-2,5,12-
trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl)ethylidene)hydrazide
dihydrochloride (zorubicin) was obtained as red-orange crystalline powder;
[α] D 20 = -50° (c=0.2 in water). The compound may be employed in the form
of different non-toxic salts such as benzoates, fumarates, maleates, tartrates
and so on. The best among these compounds proves to be daunorubicin
benzoylhydrazone (rubidazone), which is less cardiotoxic (French Pat. No.
1,578,722 published in 1967, Class CO7d).
Therapeutic Function
Antineoplastic, Antileukemic
Check Digit Verification of cas no
The CAS Registry Mumber 36508-71-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,5,0 and 8 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 36508-71:
(7*3)+(6*6)+(5*5)+(4*0)+(3*8)+(2*7)+(1*1)=121
121 % 10 = 1
So 36508-71-1 is a valid CAS Registry Number.
InChI:InChI=1/C34H35N3O10/c1-15-28(38)20(35)12-23(46-15)47-22-14-34(44,16(2)36-37-33(43)17-8-5-4-6-9-17)13-19-25(22)32(42)27-26(30(19)40)29(39)18-10-7-11-21(45-3)24(18)31(27)41/h4-11,15,20,22-23,28,38,40,42,44H,12-14,35H2,1-3H3,(H,37,43)/b36-16+
