36530-06-0Relevant articles and documents
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Meller,A.,Ossko,A.
, p. 150 - 155 (1972)
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Dual Role of Subphthalocyanine Dyes for Optical Imaging and Therapy of Cancer
van de Winckel, Eveline,Mascaraque, Marta,Zamarrón, Alicia,Juarranz de la Fuente, ángeles,Torres, Tomás,de la Escosura, Andrés
, (2018)
The family of subphthalocyanine (SubPc) macrocycles represents an interesting class of nonplanar aromatic dyes with promising features for energy conversion and optoelectronics. The use of SubPcs in biomedical research is, on the contrary, clearly underexplored, despite their documented high fluorescence and singlet oxygen quantum yields. Herein, for the first time it is shown that the interaction of these chromophores with light can also be useful for theranostic applications, which in the case of SubPcs comprise optical imaging and photodynamic therapy (PDT). In particular, the article evaluates, through a complete in vitro study, the dual-role capacity of a novel series of SubPcs as fluorescent probes and PDT agents, where the macrocycle axial substitution determines their biological activity. The 2D and 3D imaging of various cancer cell lines (i.e., HeLa, SCC-13, and A431) has revealed, for example, different subcellular localization of the studied photosensitizers (PS), depending on the axial substituent they bear. These results also show excellent photocytotoxicities, which are affected by the PS localization. With the best dual-role PS, preliminary in vivo studies have demonstrated their therapeutic potential. Overall, the present paper sets the bases for an unprecedented biomedical use of these well-known optoelectronic materials.
Third Harmonic Generation Spectroscopy of Boron Subphthalocyanine
Diaz-Garcia, Maria A.,Agullo-Lopez, Fernando,Sastre, Angela,Torres, Tomas,Torruellas, William E.,Stegeman, George I.
, p. 14988 - 14991 (1995)
The dispersive behavior of the magnitude and phase of χ3(-3ω: ω,ω,ω) of sublimated boron subphthalocyanine (SubPc) thin films has been investigated via third harmonic generation (THG) spectroscopy in the range 950-2000 nm. χ3 values, three times bigger than those obtained for phthalocyanines in the same frequency range, have been measured.A four-level model, including the ground state and three excited states associated to bands observed in the linear absorption spectrum, has been succesfully used to explain the nonlinear behavior of these compounds.
Synthesis and STM imaging of symmetric and dissymmetric ethynyl-bridged dimers of boron-subphthalocyanine bowl-shaped nanowheels
Jacquot De Rouville, Henri-Pierre,Garbage, Romain,Ample, Francisco,Nickel, Anja,Meyer, Joerg,Moresco, Francesca,Joachim, Christian,Rapenne, Gwéna?l
, p. 8925 - 8928 (2012)
The future's wheel: A new class of wheels, based on subphthalocyanine fragments, for future incorporation in functional nanovehicles is reported (see figure). The syntheses of a symmetric wheel, a nitrogen-tagged wheel, and their ethynyl-bridged homodimers are presented. Theoretical calculations and STM imaging demonstrate the advantage of a bowl-shaped structure and the efficiency of the tag for STM imaging.
Pyrene/coumarine-subphthalocyanine conjugates as light harvesting systems with intramolecular energy transfer
Decréau, Richard A.,Lioret, Vivian,Rousselin, Yoann
, (2020/08/06)
A series of subphthalocyanine-antenna dyads have been successfully designed, synthetized and characterized by 1H NMR, 13C NMR, high-resolution mass spectroscopy and X-ray diffraction for some of them. Pyrene and coumarine have been appended at the axial position of the subphthalocyanine scaffold using different types of linkers. Photophysical properties of the new compounds have been measured in toluene, tetrahydrofuran, chloroform, dimethyl sulfoxide and methanol. Energy transfer efficiencies between antenna and the subphthalocyanine platform have been investigated and almost quantitative energy transfer occurs in the antenna-platform 5.
