365441-87-8

Basic information

• Product Name: Carbamic acid, (2-methylpropyl)-, 1,1-dimethylethyl ester (9CI)
• Synonyms: Carbamic acid, (2-methylpropyl)-, 1,1-dimethylethyl ester (9CI);tert-butyl isobutylcarbamate
• CAS NO: 365441-87-8
• Molecular Formula: C₉H₁₉NO₂
• Molecular Weight: 173.25266
• Product Categories: N-BOC
• Mol File: 365441-87-8.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Carbamic acid, (2-methylpropyl)-, 1,1-dimethylethyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, (2-methylpropyl)-, 1,1-dimethylethyl ester (9CI)(365441-87-8)
• EPA Substance Registry System: Carbamic acid, (2-methylpropyl)-, 1,1-dimethylethyl ester (9CI)(365441-87-8)

Safety Data

• Hazardous Substances Data: 365441-87-8(Hazardous Substances Data)

Upstream product

• 271600-32-9 [2-methyl-1-(toluene-4-sulfonyl)-propyl]-carbamic acid tert-butyl ester 
• 503-74-2 3-methylbutyric acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 66389-76-2 tert-butyl methyl iminodicarboxylate 
• 4248-19-5 tert-butyl carbazate 
• 13734-41-3 t-Boc-L-valine 
• 34619-03-9 tert-butyldicarbonate 
• 78-81-9 isobutylamine 
• 58561-04-9 N-tert-butoxycarbonyl-L-valine methyl ester 

Downstream Products

• 1067679-06-4 (2-chloro-6-styryl-pyrimidin-4-yl)-isobutyl-carbamic acid tert-butyl ester 
• 130457-35-1 N-Boc-2-amino-3-methyl-butyronitrile 
• 1610605-58-7 tert-butyl isobutyl(4-(trifluoromethyl)phenethyl-1,2,2-D₃)carbamate 
• 5705-57-7 N-isobutyl-benzamide 
• 112753-91-0 N-isobutyl-3-phenylpropionamide 
• 1873-29-6 isobutyl isocyanate 

Relevant articles and documents

A strategy for generating alkyl radicals from aliphatic esters and lactones via sequential hydrolysis and photoinduced decarboxylation

Sequential hydrolysis and photoinduced decarboxylation of methyl aliphatic esters lead to efficient generation of alkyl radicals under mild conditions. The generated alkyl radicals react with a variety of reagents to produce addition, reduction, and substitution products. In addition, the new tin and halogen free process for alkyl radical generation is applicable to a variety of aliphatic esters including those of dipeptides, steroids, saccharides, and lactones.

Decarboxylative reduction of free aliphatic carboxylic acids by photogenerated cation radical

The decarboxylation of free carboxylic acids was effected by a photogenerated cation radical of phenanthrene to yield the reduction product in the presence of a thiol, which provides an alternative method to the Barton decarboxylation procedure for aliphatic acids such as N-Boc amino acids. The Royal Society of Chemistry.

An expedient transformation of alcohols into N-Boc-amines

t-Butyl methyl iminodicarbonate (3) can be easily alkylated with primary or secondary alcohols under Mitsunobu conditions (DIAD, TPP) to give the corresponding N-alkyl iminodicarbonates. Partial deprotection of the latter with methanolic potassium hydroxi