36556-06-6 Usage
Description
5,6,7,8-Tetrahydroisoquinoline, also referred to as Bz-tetrahydroisoquinoline, is an organic compound that belongs to the isoquinoline family. It is known for its potential applications in the synthesis of various compounds, including pharmaceuticals and other organic molecules. Reduction of 5,6,7,8-tetrahydroisoquinoline with sodium in ethanol results in the formation of trans-decahydroquinolines.
Uses
Used in Pharmaceutical Synthesis:
5,6,7,8-Tetrahydroisoquinoline is used as a key intermediate in the total synthesis of (±)-desoxycodeine-D, a compound with potential pharmaceutical applications. Its role in this synthesis highlights its importance in the development of new drugs and therapeutic agents.
Used in Organic Chemistry:
In the field of organic chemistry, 5,6,7,8-tetrahydroisoquinoline is utilized in the synthesis of 7,8-dihydroisoquinolin-5(6H)-one, a compound that may have various applications in chemical research and development. This demonstrates the versatility of 5,6,7,8-tetrahydroisoquinoline as a building block for creating diverse organic molecules.
Used in Research and Development:
5,6,7,8-Tetrahydroisoquinoline is also employed in research and development for its potential applications in creating new compounds and materials. Its unique structure and reactivity make it a valuable tool for chemists and researchers working on the design and synthesis of novel molecules with specific properties and functions.
Synthesis Reference(s)
Tetrahedron, 39, p. 2869, 1983 DOI: 10.1016/S0040-4020(01)92154-4
Check Digit Verification of cas no
The CAS Registry Mumber 36556-06-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,5,5 and 6 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 36556-06:
(7*3)+(6*6)+(5*5)+(4*5)+(3*6)+(2*0)+(1*6)=126
126 % 10 = 6
So 36556-06-6 is a valid CAS Registry Number.
InChI:InChI=1/C9H11N/c1-2-4-9-7-10-6-5-8(9)3-1/h5-7H,1-4H2
36556-06-6Relevant articles and documents
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Karrer,Enslin
, p. 1390,1399 (1949)
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Ru-Catalyzed Transfer Hydrogenation of Nitriles, Aromatics, Olefins, Alkynes and Esters
Alshakova, Iryna D.,Gabidullin, Bulat,Nikonov, Georgii I.
, p. 4860 - 4869 (2018/10/02)
This paper reports the preparation of new ruthenium(II) complexes supported by a pyrazole-phosphine ligand and their application to transfer hydrogenation of various substrates. These Ru complexes were found to be efficient catalysts for the reduction of nitriles and olefins. Heterocyclic compounds undergo transfer hydrogenation with good to moderate yields, affording examples of unusual hydrogenation of all-carbon-rings. Internal alkynes with bulky substituents show selective reduction to olefins with the unusual E–selectivity. Esters with strong electron-withdrawing groups can be reduced to the corresponding alcohols, if ethanol is used as the solvent. Possible mechanisms of hydrogenation and olefin isomerization are suggested on the basis of kinetic studies and labelling experiments.
COMPOSITIONS AND METHODS FOR THE TREATMENT OF RESPIRATORY DISORDERS
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Paragraph 0094; 0095, (2013/12/03)
The invention relates to the compounds of formula (I) or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula (I), and methods for the treatment of respiratory disorders may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of cough caused by minor throat and bronchial irritation (such as commonly accompanies the flu and common cold), as well as those resulting from inhaled particle irritants, upper respiratory infections, (pseudobulbar affect) in patients with amyotrophic lateral sclerosis and multiple sclerosis, neuropathic pain and pain associated with fibromyalgia.