36556-56-6Relevant articles and documents
Preparation method of 3,5-difluorochlorobenzene
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Paragraph 0017; 0018; 0019; 0020; 0021; 0022, (2017/08/31)
The invention discloses a preparation method of 3,5-difluorochlorobenzene, and relates to the field of organic synthesis technology. The preparation method comprises the following steps: using 2,4-difluoroaniline as a raw material, introducing chlorine into a meta-position of a benzene ring of fluorine under the limit of an amino group, and then removing amino from the benzene ring to obtain 3,5-difluorochlorobenzene. In the whole preparation process, high temperature and high pressure reaction are avoided, reaction conditions are mild, and intermediates are not required to be separated and purified, and can be directly used in reaction in a next step, so that not only can the treatment cost of the intermediates be reduced, but also the loss of yield of the intermediates caused in the purification process can be reduced, and the conversion percent of the intermediates in amino removal reaction is increased. The molar yield of the product, 3,5-difluorochlorobenzene, produced by using the method can be up to 80% and more and the purity can be up to 99.5% or more, so that the yield and purity of the product are ensured on the basis of reducing the cost of preparation, and the product, 3,5-difluorochlorobenzene, is used as a drug intermediate for preparation of drug.