366-44-9

Basic information

• Product Name: 2-CHLORO-N-(4-FLUORO-2-METHYLPHENYL)ACETAMIDE
• Synonyms: 2-CHLORO-N-(4-FLUORO-2-METHYLPHENYL)ACETAMIDE;2-chloro-N-(4-fluoro-2-methylphenyl)acetamide(SALTDATA: FREE);2-chloro-N-(4-fluoro-2-methyl-phenyl)ethanamide
• CAS NO: 366-44-9
• Molecular Formula: C₉H₉ClFNO
• Molecular Weight: 201.63
• Mol File: 366-44-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 323.632°C at 760 mmHg
• Flash Point: 149.527°C
• Appearance: /
• Density: 1.306g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.564
• CAS DataBase Reference: 2-CHLORO-N-(4-FLUORO-2-METHYLPHENYL)ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-N-(4-FLUORO-2-METHYLPHENYL)ACETAMIDE(366-44-9)
• EPA Substance Registry System: 2-CHLORO-N-(4-FLUORO-2-METHYLPHENYL)ACETAMIDE(366-44-9)

Safety Data

• Hazardous Substances Data: 366-44-9(Hazardous Substances Data)

Usage

General Description

2-CHLORO-N-(4-FLUORO-2-METHYLPHENYL)ACETAMIDE is a chemical compound with the formula C9H8ClFN2O. It is an amide derivative, which contains a chlorine atom and a fluorine atom attached to a phenyl ring, as well as a methyl group. 2-CHLORO-N-(4-FLUORO-2-METHYLPHENYL)ACETAMIDE is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It exhibits biological activity as an antimicrobial and antifungal agent and has potential applications in the development of new drugs. Additionally, it can be used as a building block in organic synthesis for the preparation of various organic compounds. Overall, 2-CHLORO-N-(4-FLUORO-2-METHYLPHENYL)ACETAMIDE has significant value in the field of medicinal chemistry and chemical research.

InChI:InChI=1/C9H9ClFNO/c1-6-4-7(11)2-3-8(6)12-9(13)5-10/h2-4H,5H2,1H3,(H,12,13)

Upstream product

• 452-71-1 4-fluor-2-methylaniline 
• 79-04-9 chloroacetyl chloride 
• 446-33-3 5-Fluoro-2-nitrotoluene 

Downstream Products

• 697305-34-3 (2R,3S)-2-({[4-(4-fluoro-2-methylphenyl)-3-oxopiperazin-1-yl]carbonyl}amino)-3-(1H-indol-3-yl)butanoic acid 
• 697308-68-2 N-[(1R,2S)-1-({[5-[(dimethylamino)methyl]-2-ethoxyphenyl]amino}carbonyl)-2-(1H-indol-3-yl)propyl]-4-(4-fluoro-2-methylphenyl)-3-oxopiperazine-1-carboxamide 
• 697304-78-2 ethyl (2R,3S)-2-({[4-(4-fluoro-2-methylphenyl)-3-oxopiperazin-1-yl]carbonyl}amino)-3-(1H-indol-3-yl)butanoate 
• 697305-50-3 1-(4-fluoro-2-methylphenyl)piperazin-2-one hydrochloride 
• 697305-46-7 N-(4-fluoro-2-methylphenyl)-2-[(2-hydroxyethyl)amino]acetamide 
• 147285-87-8 4-fluoro-2-methyl-6-nitrophenylamine 

Relevant articles and documents

Synthesis and Biological Evaluation of Dithiobisacetamides as Novel Urease Inhibitors

Thirty-eight disulfides containing N-arylacetamide were designed and synthesized in an effort to develop novel urease inhibitors. Biological evaluation revealed that some of the synthetic compounds exhibited strong inhibitory potency against both cell-free urease and urease in intact cell with low cytotoxicity to mammalian cells even at concentration up to 250 μM. Of note, 2,2′-dithiobis(N-(2-fluorophenyl)acetamide) (d7), 2,2′-dithiobis(N-(3,5-difluorophenyl)acetamide) (d24), and 2,2′-dithiobis(N-(3-fluorophenyl)acetamide) (d8) were here identified as the most active inhibitors with IC50 of 0.074, 0.44, and 0.81 μM, showing 32- to 355-fold higher potency than the positive control acetohydroxamic acid. These disulfides were confirmed to bind urease without covalent modification of the cysteine residue and to inhibit urease reversibly with a mixed inhibition mechanism. They also showed very good anti-Helicobacter pylori activities with d8 showing a comparable potency to the clinical used drug amoxicillin. The impressive in vitro biological profile indicated their immense potential as therapeutic agents to tackle H. pylori caused infections.

FGFR4 INHIBITOR AND PREPARATION METHOD AND USE THEREOF

Provided are a class of compounds as shown in formula (I) as FGFR4 inhibitors, and pharmaceutically acceptable salts thereof, preparation methods therefor and the use thereof in the preparation of drugs for treating FGFR4-related diseases.

Acetamides and benzamides that are useful in treating sexual dysfunction

The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.