366-62-1

Basic information

• Product Name: 2-(4-fluoro-phenyl)-1-pyridin-2-yl-ethanone
• Synonyms: 2-(4-fluoro-phenyl)-1-pyridin-2-yl-ethanone
• CAS NO: 366-62-1
• Molecular Weight: 215.227
• Mol File: 366-62-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-(4-fluoro-phenyl)-1-pyridin-2-yl-ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-fluoro-phenyl)-1-pyridin-2-yl-ethanone(366-62-1)
• EPA Substance Registry System: 2-(4-fluoro-phenyl)-1-pyridin-2-yl-ethanone(366-62-1)

Safety Data

• Hazardous Substances Data: 366-62-1(Hazardous Substances Data)

Upstream product

• 1749-29-7 2-pyridylmethyllithium 
• 403-33-8 methyl 4-flurobenzoate 
• 109-06-8 α-picoline 
• 451-46-7 4-fluorobenzoic acid ethyl ester 
• 10366-88-8 4-fluoro-N,N-diethyl-benzamide 
• 108-89-4 picoline 
• 403-43-0 4-fluorobenzoyl chloride 
• 116332-54-8 4-fluoro-N-methoxy-N-methylbenzamide 

Downstream Products

• 1435892-95-7 2-(4-fluorophenyl)-4H-quinolizin-4-one 
• 1430074-90-0 (4-fluorophenyl)(3-phenylimidazo[1,5-α]pyridin-1-yl)methanone 
• 301836-30-6 4-[4-(4-Fluorophenyl)-5-(pyridin-2-yl)-1H-imidazol-2-yl]benzoic acid 
• 301836-28-2 2-(4-cyanophenyl)-4-(4-fluorophenyl)-N-1-hydroxy-5-(2-pyridyl)-imidazole 
• 301836-29-3 4-[4-(4-fluorophenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzonitrile 
• 861804-62-8 4-[5-(4-fluoro-phenyl)-4-pyridin-2-yl-1H-pyrrol-2-yl]-piperidine-1-carboxylic acid benzyl ester 
• 861804-87-7 4-[4-(4-fluoro-phenyl)-4-oxo-3-pyridin-2-yl-butyryl]-piperidine-1-carboxylic acid benzyl ester 

Relevant articles and documents

Highly efficient asymmetric bioreduction of 1-aryl-2-(azaaryl)ethanones. Chemoenzymatic synthesis of lanicemine

Different ketoreductases (KREDs) have been used to promote a highly selective reduction of several 1-aryl-2-(azaaryl)ethanones (azaaryl = pyridinyl, quinolin-2-yl), the corresponding secondary alcohols being obtained with very high yields and enantiomeric excesses (ee > 99%). The absolute configuration of each optically active alcohol has been assigned by means of modified Mosher and Kelly methods, two shielding effects being evaluated: (1) the Mosher phenyl ring effect on the azaaryl protons and (2) the one of the azaaryl ring on the Mosher methoxy group. In addition, the biologically active amine lanicemine has been synthesized from (R)-1-phenyl-2-(pyridin-2-yl)ethanol, thus proving the utility of the secondary alcohols here prepared.

The application of flow microreactors to the preparation of a family of casein kinase i inhibitors

In this article we demonstrate how a combination of enabling technologies such as flow synthesis, solid-supported reagents and scavenging resins utilised under fully automated software control can assist in typical medicinal chemistry programmes. In particular automated continuous flow methods have greatly assisted in the optimisation of reaction conditions and facilitated scale up operations involving hazardous chemical materials. Overall a collection of twenty diverse analogues of a casein kinase I inhibitor has been synthesised by changing three principle binding vectors.

Identification of novel inhibitors of the transforming growth factor β1 (TGF-β1) type 1 receptor (ALK5)

Screening of our internal compound collection for inhibitors of the transforming growth factor β1 (TGF-β1) type I receptor (ALK5) identified several hits. Optimization of the dihydropyrroloimidazole hit 2 by introduction of a 2-pyridine and 3,4-methylenedioxyphenyl group gave 7, a selective ALK5 inhibitor. With this information, optimization of the triarylimidazole hit 8 gave the selective inhibitor 14, which inhibits TGF-β1-induced fibronectin mRNA formation while displaying no measurable cytotoxicity in the 48 h XTT assay.