366-93-8 Usage
Description
AY 9944 is a compound that functions as a cholesterol synthesis inhibitor and a sonic hedgehog inhibitor. It is known to inhibit both 7-dehydrocholesterol 7-reductase and 8,7-sterol isomerase, playing a significant role in the regulation of cholesterol synthesis. Additionally, AY 9944 acts as an inhibitor of hedgehog (Hh) signaling, which is crucial in various biological processes and has implications in the development of certain diseases.
Uses
Used in Pharmaceutical Industry:
AY 9944 is used as a cholesterol synthesis inhibitor for its ability to regulate cholesterol synthesis by inhibiting key enzymes involved in the process. This makes it a potential candidate for the development of drugs targeting hypercholesterolemia and related cardiovascular diseases.
AY 9944 is also used as a sonic hedgehog inhibitor for its role in modulating hedgehog signaling, which is involved in various developmental and disease processes. Its inhibition can be beneficial in the development of therapeutic strategies for conditions associated with aberrant hedgehog signaling, such as certain cancers and congenital disorders.
Used in Research Applications:
AY 9944 is used as a research tool for studying the roles of cholesterol synthesis and hedgehog signaling in cellular processes and disease development. Its ability to inhibit these pathways allows researchers to investigate the underlying mechanisms and potential therapeutic targets for various conditions.
Biological Activity
Inhibitor of hedgehog (Hh) signaling, possibly via several mechanisms. Inhibits Δ 7 -dehydrocholesterol reductase (IC 50 = 13 nM), thus reduces cholesterol biosynthesis, and also inhibits cholesterol esterification. May also directly block the cellular response to Hh proteins. Teratogenic in vivo .
Safety Profile
Poison by ingestion.Experimental teratogenic and reproductive effects.Inhibits cholesterol synthesis. When heated todecomposition it emits very toxic fumes of NOx and Cl-.
references
[1]. moebius, f.f., et al., molecular cloning and expression of the human delta7-sterol reductase. proc natl acad sci u s a, 1998. 95(4): p. 1899-902.[2]. achour, a., et al., restoration of immune response by a cationic amphiphilic drug (ay 9944) in vitro: a new approach to chemotherapy against human immunodeficiency virus type 1. antimicrob agents chemother, 1998. 42(10): p. 2482-91. [3]. xu, l., et al., novel oxysterols observed in tissues and fluids of ay9944-treated rats: a model for smith-lemli-opitz syndrome. j lipid res, 2011. 52(10): p. 1810-20.
Check Digit Verification of cas no
The CAS Registry Mumber 366-93-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,6 and 6 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 366-93:
(5*3)+(4*6)+(3*6)+(2*9)+(1*3)=78
78 % 10 = 8
So 366-93-8 is a valid CAS Registry Number.
InChI:InChI=1/C22H28Cl2N2.2ClH/c23-21-7-3-1-5-19(21)15-25-13-17-9-11-18(12-10-17)14-26-16-20-6-2-4-8-22(20)24;;/h1-8,17-18,25-26H,9-16H2;2*1H/t17-,18-;;
