366004-54-8

Basic information

• Product Name: N-(2-pent-1-ynyl-phenyl)-butyramide
• Synonyms: N-(2-pent-1-ynyl-phenyl)-butyramide
• CAS NO: 366004-54-8
• Molecular Weight: 229.322
• Mol File: 366004-54-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(2-pent-1-ynyl-phenyl)-butyramide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-pent-1-ynyl-phenyl)-butyramide(366004-54-8)
• EPA Substance Registry System: N-(2-pent-1-ynyl-phenyl)-butyramide(366004-54-8)

Safety Data

• Hazardous Substances Data: 366004-54-8(Hazardous Substances Data)

Upstream product

• 28033-54-7 butyric acid-(2-hydroxy-anilide) 
• 627-19-0 1-Pentyne 
• 366004-39-9 trifluoro-methanesulfonic acid 2-butyrylamino-phenyl ester 

Downstream Products

• 13228-41-6 2-propyl-indole 

Relevant articles and documents

Chemistry of aminophenols. Part 1: Remarkable additive effect on Sonogashira cross-coupling of 2-carboxamidoaryl triflates and application to novel synthesis of indoles

A novel and general synthesis of indoles has been established by utilizing 2-aminophenols as the starting materials. The key step is a modified Pd(0)-Cu(I)-catalyzed cross-coupling of 1-alkynes with 2-carboxamidoaryl triflates in the presence of n-Bu4NI as the additive. The 2-alkynylanilides obtained were subjected to an alkoxide-mediated cyclization to provide a number of indole containing compounds possessing substituents at the C2, C4, C5, and/or C6 position(s) in good overall yields.