36614-32-1 Usage
Description
9-OXO-15S-HYDROXY-PROSTA-5Z,8(12),13E,17Z-TETRAEN-1-OIC ACID, also known as Prostaglandin B3 (PGB3), is a non-enzymatic dehydration product derived from the treatment of Prostaglandin E3 (PGE3) with a strong base. It is a type of prostaglandin, which are lipid compounds that act as signaling molecules and have various physiological effects. PGB3 has been studied for its affinity to human PPARγ, a nuclear receptor that plays a role in the regulation of cellular differentiation, development, and metabolism.
Uses
Used in Pharmaceutical Industry:
PGB3 is used as a research compound for studying the structure-activity relationship of prostaglandins and their interaction with human PPARγ. Its lower affinity compared to other prostaglandins like PGB1 and PGB2 makes it a valuable tool for understanding the molecular mechanisms underlying their binding and potential therapeutic applications.
Used in Research and Development:
PGB3 serves as a key compound in the development of new drugs targeting PPARγ, which is involved in various diseases, including diabetes, atherosclerosis, and certain cancers. By studying the differences in affinity between PGB3 and other prostaglandins, researchers can gain insights into the design of more effective and selective PPARγ modulators.
Check Digit Verification of cas no
The CAS Registry Mumber 36614-32-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,6,1 and 4 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 36614-32:
(7*3)+(6*6)+(5*6)+(4*1)+(3*4)+(2*3)+(1*2)=111
111 % 10 = 1
So 36614-32-1 is a valid CAS Registry Number.
