36637-18-0 Usage
Description
Etidocaine, also known as Duranest, is an amino acid amide local anesthetic that combines 2-[ethyl(propyl)amino]butanoic acid and 2,6-dimethylaniline to form the amide bond. It is characterized by its rapid onset and long-lasting action properties, which are similar to those of bupivacaine.
Uses
Used in Medical Procedures:
Etidocaine is used as a local anesthetic for various medical procedures, including surgical operations and labor and delivery. It provides effective pain relief and numbness to the targeted area, allowing for minimal discomfort and a smoother procedure.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Etidocaine is used as a key component in the formulation of local anesthetic medications. Its rapid onset and long-lasting effects make it a valuable asset in the development of anesthetic drugs for various applications.
Brand Name:
Duranest [as hydrochloride] (Astra) is the brand name under which Etidocaine is marketed, specifically in its hydrochloride form. This brand is widely recognized and trusted for its effectiveness in providing anesthesia during medical procedures.
Originator
Duranest,Astra,US,1976
Manufacturing Process
α-(n-Propylamino)-n-butyro-2,6-xylidide(0.243 mol) and freshly distilled
diethyl sulfate (1.6 mols were mixed in a flask equipped with reflux condenser,
drying tube and stirrer. The mixture was stirred for 5 hours at 90°C. After
cooling, water (110 ml) was added with stirring for 15 minutes followed by 4M
HCl (110 ml). The solution was washed with ether (3 X 100 ml) and made
alkaline with 7M NaOH to pH 10-11. The freed base was taken up in ether (3
X 100 ml); the extracts were dried over sodium sulfate, filtered and
evaporated. The residue was dissolved in absolute ether (200 ml) and the
hydrochloride prepared by addition of ethereal hydrogen chloride. The
precipitate was filtered, washed with ether, and recrystallized twice from
absolute ethanol/ether and from isopropanol/isopropylether; MP 203°C to
203.5°C; yield: 0.126 mol (52%).
The starting material is prepared by reacting 2-bromobutyric acid with sulfonyl
chloride to give the acid chloride. It is then reacted with 2,6-xylidine, then
with potassium iodide followed by n-propylamine.
Therapeutic Function
Local anesthetic
Check Digit Verification of cas no
The CAS Registry Mumber 36637-18-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,6,3 and 7 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 36637-18:
(7*3)+(6*6)+(5*6)+(4*3)+(3*7)+(2*1)+(1*8)=130
130 % 10 = 0
So 36637-18-0 is a valid CAS Registry Number.
InChI:InChI=1S/C17H28N2O/c1-6-12-19(8-3)15(7-2)17(20)18-16-13(4)10-9-11-14(16)5/h9-11,15H,6-8,12H2,1-5H3,(H,18,20)
