36680-26-9Relevant articles and documents
Ru(II)–NNO pincer-type complexes catalysed E-olefination of alkyl-substituted quinolines/pyrazines utilizing primary alcohols
Balamurugan, Gunasekaran,Malecki, Jan Grzegorz,Ramesh, Rengan,Tamilthendral, Veerappan
, (2022/01/08)
An efficient and selective E-olefination of alkyl-substituted quinolines and pyrazines through acceptorless dehydrogenative coupling of alcohols catalysed by Ru(II)–N^N^O pincer-type complexes encompassing carbonyl and triphenylarsines as co-ligands is de
Preparation method of alkyl/alkenyl substituted nitrogen-containing heterocyclic compound
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Paragraph 0066-0074, (2021/07/10)
The invention belongs to the technical field of organic synthesis, and particularly discloses a preparation method of an alkyl/alkenyl substituted nitrogen-containing heterocyclic compound, which comprises the following steps: (1) adding a 2-methyl nitrogen-containing heterocyclic compound, primary alcohol, alkali and an additive into an organic solvent, performing stirring reaction for 24 hours, and then cooling the product to room temperature; and (2) concentrating, separating and purifying the reaction liquid obtained in the step (1). The simple and effective method for preparing the alkyl/alkenyl substituted nitrogen-containing heterocyclic compound under the metal-free and ligand-free conditions is realized, the 2-methyl nitrogen-containing heterocyclic compound and the primary alcohol which are economical and easy to obtain are used as raw materials, and the alkyl/alkenyl substituted nitrogen-containing heterocyclic compound is prepared under the synergistic promotion of alkali and additives; and methyl alkylation and alkenylation reaction are carried out to generate the corresponding alkyl/alkenyl substituted nitrogen-containing heterocyclic compound. The product has high application value and can be used in the fields of spices, medicines, materials, organic synthesis and the like. The method is wide in application range, simple in process, green, simple, high in yield and suitable for popularization and application.
Method for alkenylation of methyl heterocyclic compound
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Paragraph 0115-0118, (2021/02/10)
The invention discloses a method for alkenylation of methyl heterocyclic compound, which is a green method for synthesizing an alkenyl heterocyclic compound by carrying out alkenylation reaction on methyl under the condition that the methyl heterocyclic compound and alcohol do not need to participate in a transition metal catalyst. According to the method, alcohol which is cheap, easy to obtain, wide in source, stable and low in toxicity is used as an alkenylation reagent, no transition metal catalyst or ligand is needed, air can be directly used as a convenient, mild and efficient oxidizing agent under the action of common water-soluble inorganic base, and the method is suitable for industrial production. The alkenyl heterocyclic compound is directly synthesized by carrying out a Cenylation reaction with a methyl heterocyclic compound through processes such as oxidative condensation and the like. The method has the advantages of simple reaction conditions, no need of inert gas protection, low requirements on equipment, easiness in operation, water as a byproduct, easiness in removal of water-soluble inorganic base, no metal residue in the product, easiness in purification, suitability for heterocyclic systems such as quinoline, quinoxaline, pyridine, benzothiazole and the like, and wide application range, thereby having certain research significance and potential application prospect.
