367-86-2 Usage
Description
4-Fluoro-3-nitrobenzotrifluoride is a clear yellow liquid with significant applications in the field of chemistry, particularly in the synthesis and detection of various compounds.
Uses
Used in Chromatography:
4-Fluoro-3-nitrobenzotrifluoride is used as a derivatization reagent in the pre-column derivatization technique for High-Performance Liquid Chromatography (HPLC) with UV/VIS spectrophotometric detection of polyamines. This application aids in the detection and analysis of these biologically important compounds.
Used in Synthesis:
4-Fluoro-3-nitrobenzotrifluoride serves as a key intermediate in the synthesis of various compounds, including:
1. 2-nitro-4-trifluoromethylphenylhydrazine, which acts as a derivatization reagent for 1,2-diol compounds and oxo-steroids.
2. [3-(2-nitro-4-trifluoromethylphenyl)aminophenyl]dihydroxyborane, another derivatization reagent for 1,2-diol compounds and oxo-steroids.
3. 1-(3-chlorophenyl)-5-trifluoromethyl-3-hydrobenzimidazol-2-one, which is utilized in the development of novel chemical entities with potential applications in various fields.
These applications highlight the versatility and importance of 4-Fluoro-3-nitrobenzotrifluoride in the chemical industry, particularly in the development of new compounds and the enhancement of analytical techniques.
Check Digit Verification of cas no
The CAS Registry Mumber 367-86-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,6 and 7 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 367-86:
(5*3)+(4*6)+(3*7)+(2*8)+(1*6)=82
82 % 10 = 2
So 367-86-2 is a valid CAS Registry Number.
InChI:InChI=1/C7H5F2NO2/c8-4-5-1-2-6(9)7(3-5)10(11)12/h1-3H,4H2
367-86-2Relevant articles and documents
Efficient phosphorus catalysts for the halogen-exchange (Halex) reaction
Lacour, Marie-Agnes,Zablocka, Maria,Duhayon, Carine,Majoral, Jean-Pierre,Taillefer, Marc
supporting information; experimental part, p. 2677 - 2682 (2009/10/20)
New families of monomeric to dendritic, and monocationic to multicationic (PNP) compounds have been prepared and tested as catalysts in halogen exchange (Halex) reactions. Some of them allow an increase in the efficiency of these reactions which are performed in some cases under the mildest conditions reported up to now.
THE SYNTHESIS OF ORGANOFLUORINE COMPOUNDS USING POTASSIUM FLUORIDE-TETRAPHENYLPHOSPHONIUM BROMIDE SYSTEMS.
Clark, James H.,Macquarrie, Duncan J.
, p. 111 - 114 (2007/10/02)
The reactivity of potassium fluoride in nucleophilic fluorine transfer reactions can appreciably enhanced by the presence of tetraphenyl phosphonium bromide.Rate accelerations are especially large in non dipolar aprotic solvents.
Thieno[3,2-b]-[1,5]benzodiazepines
-
, (2008/06/13)
Thieno[1,5]benzodiazepines having useful CNS activity containing the novel tricyclic ring system: STR1 the 10-position being substituted by an amino, preferably a piperazino, group.
