36717-48-3

Basic information

• Product Name: 3-Furancarboxylic acid, 2-ethoxy-4,5-dihydro-4-oxo-, ethyl ester
• Synonyms: ethyl 2-ethoxy-4-oxo-4,5-dihydrofuran-3-carboxylate;2-ethoxy-4-oxo-4,5-dihydro-furan-3-carboxylic acid ethyl ester;ethyl 2-ethoxy-4-oxo-4,5-dihydofuran-3-carboxylate;3-Furancarboxylic acid,2-ethoxy-4,5-dihydro-4-oxo-,ethyl ester;3-carboethoxy-2-ethoxy-4,5-dihydrofuran-4-one;ethyl 2-ethoxy-4-furanone-3-carboxylate;ethyl 2-ethoxy-4,5-dihydro-4-oxofuran-3-carboxylate;2-Aethoxy-4-oxo-4,5-dihydro-furan-3-carbonsaeure-aethylester
• CAS NO: 36717-48-3
• Molecular Formula: C9H12O5
• Molecular Weight: 200.191
• Mol File: 36717-48-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 322.2±42.0 °C(Predicted)
• Density: 1.21±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 3-Furancarboxylic acid, 2-ethoxy-4,5-dihydro-4-oxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Furancarboxylic acid, 2-ethoxy-4,5-dihydro-4-oxo-, ethyl ester(36717-48-3)
• EPA Substance Registry System: 3-Furancarboxylic acid, 2-ethoxy-4,5-dihydro-4-oxo-, ethyl ester(36717-48-3)

Safety Data

• Hazardous Substances Data: 36717-48-3(Hazardous Substances Data)

Upstream product

• 79-04-9 chloroacetyl chloride 
• 105-53-3 diethyl malonate 

Downstream Products

• 58337-16-9 ethyl 4,5-dihydro-4-oxo-2-(phenylamino)-3-furancarboxylate 
• 484-74-2 iso-dictamnine 
• 75478-38-5 4-Hydroxy-5-[1-hydroxy-3-phenyl-prop-(Z)-ylidene]-2-oxo-2,5-dihydro-furan-3-carboxylic acid ethyl ester 
• 75478-37-4 2-Ethoxy-5-[1-hydroxy-3-phenyl-prop-(Z)-ylidene]-4-oxo-4,5-dihydro-furan-3-carboxylic acid ethyl ester 
• 1402055-93-9 ethyl 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-2-{[4-(2-hydroxyethoxy)-2-methylphenyl]amino}-4-oxo-4,5-dihydrofuran-3-carboxylate 
• 1402056-79-4 cyclopropylmethyl 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-2-{[4-(2-hydroxyethoxy)-2-methylphenyl]amino}-4-oxo-4,5-dihydrofuran-3-carboxylate 
• 1402056-84-1 n-butyl 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-2-{[4-(2-hydroxyethoxy)-2-methylphenyl]amino}-4-oxo-4,5-dihydrofuran-3-carboxylate 
• 1402056-85-2 isopropyl 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-2-{[4-(2-hydroxyethoxy)-2-methylphenyl]amino}-4-oxo-4,5-dihydrofuran-3-carboxylate 
• 1402059-89-5 C₁₇H₂₂N₂O₅ 
• 1402056-50-1 ethyl 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-2-({4-[(dimethylamino)methyl]-2-methylphenyl}amino)-4-oxo-4,5-dihydrofuran-3-carboxylate 
• 1402056-87-4 ethyl 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-2-[(cyclohexylmethyl)amino]-4-oxo-4,5-dihydrofuran-3-carboxylate 
• 1402056-68-1 ethyl 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-2-({2-methyl-4-[2-(4-methylpiperazinyl)ethoxy]phenyl}amino)-4-oxo-4,5-dihydrofuran-3-carboxylate acetate 
• 58337-23-8 2-(N-phenylamino)-4,5-dihydro-4-oxo-3-furancarboxylic acid 

Relevant articles and documents

Synthesis, design, and structure–activity relationship of the pyrimidone derivatives as novel selective inhibitors of plasmodium falciparum dihydroorotate dehydrogenase

The inhibition of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) potentially represents a new treatment option for malaria, as P. falciparum relies entirely on a de novo pyrimidine biosynthetic pathway for survival. Herein, we report a series of pyrimidone derivatives as novel inhibitors of PfDHODH. The most potent compound, 26, showed high inhibition activity against PfDHODH (IC50 = 23 nM), with >400-fold species selectivity over human dihydroorotate dehydrogenase (hDHODH). The brand-new inhibitor scaffold targeting PfDHODH reported in this work may lead to the discovery of new antimalarial agents.

Studies of heterocyclic compounds. VIII. Synthesis, anti-inflammatory and antiallergic activities of N-alkyl-2,3,4,9-tetrahydrofuro[2,3-b]quinoline-3,4-diones and related compounds

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Pyrimidone derivative and application thereof

The invention relates to a pyrimidone derivative and application thereof. The pyrimidone derivative is a compound shown as a formula I or pharmaceutically-acceptable salt thereof. An activity inhibition experiment discovers that the pyrimidone derivative provided by the invention has a significant activity inhibition effect on dihydroorotate dehydrogenase of plasmodium falciparum. The invention lays a foundation for the preparation of a novel anti-malarial drug. In the formula I, R1 is a straight chain and a branched chain of C1-C6 or cyclic alkyl or amino; and A is a 5 to 6-membered saturatedor unsaturated carbocyclic group.

Novel selective and potent inhibitors of malaria parasite dihydroorotate dehydrogenase: Discovery and optimization of dihydrothiophenone derivatives

Taking the emergence of drug resistance and lack of effective antimalarial vaccines into consideration, it is of significant importance to develop novel antimalarial agents for the treatment of malaria. Herein, we elucidated the discovery and structure-activity relationships of a series of dihydrothiophenone derivatives as novel specific inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH). The most promising compound, 50, selectively inhibited PfDHODH (IC50 = 6 nM, with >14 000-fold species-selectivity over hDHODH) and parasite growth in vitro (IC50 = 15 and 18 nM against 3D7 and Dd2 cells, respectively). Moreover, an oral bioavailability of 40% for compound 50 was determined from in vivo pharmacokinetic studies. These results further indicate that PfDHODH is an effective target for antimalarial chemotherapy, and the novel scaffolds reported in this work might lead to the discovery of new antimalarial agents.