3672-50-2

Basic information

• Product Name: 5-(4-nitrophenyl)-3-phenylisoxazole
• Synonyms: 5-(4-nitrophenyl)-3-phenylisoxazole
• CAS NO: 3672-50-2
• Molecular Weight: 266.256
• Mol File: 3672-50-2.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 5-(4-nitrophenyl)-3-phenylisoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-nitrophenyl)-3-phenylisoxazole(3672-50-2)
• EPA Substance Registry System: 5-(4-nitrophenyl)-3-phenylisoxazole(3672-50-2)

Safety Data

• Hazardous Substances Data: 3672-50-2(Hazardous Substances Data)

Upstream product

• 122-04-3 4-nitro-benzoyl chloride 
• 532-27-4 1-chloroacetophenone 
• 536-74-3 phenylacetylene 
• 3672-66-0 1-(4-nitrophenyl)-3-phenylprop-2-yn-1-one 
• 20432-02-4 1-(4-nitro-phenyl)-3-phenyl-propenone 
• 62459-77-2 (4R,5R)-4-Nitro-5-(4-nitro-phenyl)-3-phenyl-4,5-dihydro-isoxazole 
• 5400-95-3 1-(4-nitro-phenyl)-3-phenyl-propane-1,3-dione 
• 38895-96-4 p-nitrochalcone dibromide 
• 23893-30-3 1-(4-nitrophenyl)-3-phenyl-2,3-dibromopropan-1-one 
• 14659-65-5 5-(4-nitrophenyl)-3-phenyl-4,5-dihydroisoxazole 
• 5633-36-3 [3-(4-nitro-phenyl)-oxiranyl]-phenyl-methanone 
• 2039-49-8 3,5-diphehylisoxazole 
• 92438-05-6 [3-(4-nitro-phenyl)-oxiranyl]-phenyl-methanone oxime 
• 62459-77-2 4-nitro-5-(4-nitro-phenyl)-3-phenyl-4,5-dihydro-isoxazole 

Downstream Products

• 80223-17-2 2-Methyl-5-(4-nitro-phenyl)-3-phenyl-isoxazol-2-ium; iodide 

Relevant articles and documents

3, 5-disubstituted isoxazole derivative and synthesis method thereof

The invention provides a 3, 5-disubstituted isoxazole derivative and a synthesis method thereof, and belongs to the technical field of organic synthesis medicines and medical intermediates. The method comprises the following steps: adding a proper solvent

An Intramolecular Wittig Approach toward Heteroarenes: Synthesis of Pyrazoles, Isoxazoles, and Chromenone-oximes

α-Halohydrazones/ketoximes are transformed into trisubstituted pyrazoles/disubstituted isoxazoles by treatment with phosphine, acyl chloride, and a base. Mechanistic investigations revealed the in situ formation of azo/nitroso olefin intermediates which underwent a tandem phospha-Michael/N- or O-acylation/intramolecular Wittig reaction to afford the heteroarenes in moderate to good yields. Further, proper functionalization of α-haloketoximes and a change of conditions allowed the chemoselective synthesis of chromenone-oximes as well as rearranged isoxazoles, thereby realizing a diversity-oriented synthesis.

Synthesis of 3,5-diarylisoxazoles under solvent-free conditions using iodobenzene diacetate

A simple and efficient method has been developed for conversion of chalcone oximes to 3,5-diaryl isoxazoles in excellent yields under solvent-free conditions. The synthesized compounds were characterized by infrared spectroscopy, 1H NMR, 13C NMR and HRMS.