367259-79-8

Basic information

• Product Name: (2S,4R)-1-((S)-2-tert-Butoxycarbonylamino-2-cyclohexyl-acetyl)-4-(3-hydroxy-1,1-dimethyl-propoxy)-pyrrolidine-2-carboxylic acid methyl ester
• Synonyms: (2S,4R)-1-((S)-2-tert-Butoxycarbonylamino-2-cyclohexyl-acetyl)-4-(3-hydroxy-1,1-dimethyl-propoxy)-pyrrolidine-2-carboxylic acid methyl ester
• CAS NO: 367259-79-8
• Molecular Weight: 470.607
• Mol File: 367259-79-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,4R)-1-((S)-2-tert-Butoxycarbonylamino-2-cyclohexyl-acetyl)-4-(3-hydroxy-1,1-dimethyl-propoxy)-pyrrolidine-2-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4R)-1-((S)-2-tert-Butoxycarbonylamino-2-cyclohexyl-acetyl)-4-(3-hydroxy-1,1-dimethyl-propoxy)-pyrrolidine-2-carboxylic acid methyl ester(367259-79-8)
• EPA Substance Registry System: (2S,4R)-1-((S)-2-tert-Butoxycarbonylamino-2-cyclohexyl-acetyl)-4-(3-hydroxy-1,1-dimethyl-propoxy)-pyrrolidine-2-carboxylic acid methyl ester(367259-79-8)

Safety Data

• Hazardous Substances Data: 367259-79-8(Hazardous Substances Data)

Upstream product

• 367259-01-6 (2S,4R)-4-(3-Benzyloxy-1,1-dimethyl-propoxy)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 763-32-6 2-methyl-1-buten-4-ol 
• 109183-71-3 N-(tert-butoxycarbonyl)-L-cyclohexylglycine 
• 367259-02-7 (2S,4R)-4-(3-Hydroxy-1,1-dimethyl-propoxy)-pyrrolidine-2-carboxylic acid methyl ester 
• 58558-53-5 (((3-methylbut-3-en-1-yl)oxy)methyl)benzene 

Relevant articles and documents

Syntheses of novel 4-tert-alkyl ether proline-based 16- and 17-membered macrocyclic compounds

Starting from N-Cbz-4-hydroxyproline methyl ester 1, a boron trifluoride-diethyl etherate-catalyzed reaction provided 4-tert-alkyl ether proline 4. Two deprotections and amide bond formations furnished the phenol alcohol 2. The macrocyclization of 2 was accomplished through a Mitsunobu reaction using triphenylphosphine and 1,1′-(azodicarbonyl)dipiperidine (ADDP), to afford novel 16- and 17-membered proline-based macrocyclic compounds of type 3.