36739-30-7

Basic information

• Product Name: 3-Pyridinol, 2-(4-methylphenyl)-
• Synonyms: 2-p-tolyl-pyridin-3-ol;2-Tolyl-3-oxypyridin;2-(4-methylphenyl)-3-pyridiol
• CAS NO: 36739-30-7
• Molecular Formula: C12H11NO
• Molecular Weight: 185.225
• Mol File: 36739-30-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 3-Pyridinol, 2-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinol, 2-(4-methylphenyl)-(36739-30-7)
• EPA Substance Registry System: 3-Pyridinol, 2-(4-methylphenyl)-(36739-30-7)

Safety Data

• Hazardous Substances Data: 36739-30-7(Hazardous Substances Data)

Upstream product

• 4467-06-5 2-(4-methylphenyl)pyridine 
• 106-49-0 p-toluidine 
• 109-00-2 3-HYDROXYPYRIDINE 
• 2028-84-4 p-methylbenzenediazonium chloride 
• 6602-32-0 2-bromo-pyridin-3-ol 
• 5720-05-8 4-methylphenylboronic acid 
• 29540-83-8 p-tolyl triflate 
• 13365-62-3 furan-2-yl-p-tolyl-methanone 

Downstream Products

• 906462-58-6 2-p-tolylpyridin-3-yl trifluoromethanesulfonate 

Relevant articles and documents

Frozen aryldiazonium chlorides in radical reactions with alkenes and arenes

Frozen aryldiazonium chlorides have been investigated in radical alkene and arene functionalizations. Through freezing at – 84 °C, aryldiazonium chlorides, which otherwise show significant decomposition in aqueous solution after several hours at room temp

Design, Synthesis, and Biological Evaluation of Novel 2-(Pyridin-3-yloxy)acetamide Derivatives as Potential Anti-HIV-1 Agents

Through a structure-based molecular hybridization and bioisosterism approach, a series of novel 2-(pyridin-3-yloxy)acetamide derivatives were designed, synthesized, and evaluated for their anti-HIV activities in MT-4 cell cultures. Biological results showed that three compounds (Ia, Ih, and Ij) exhibited moderate inhibitory activities against wild-type (wt) HIV-1 strain (IIIB) with EC50 values ranging from 8.18 μm to 41.52 μm. Among them, Ij was the most active analogue possessing an EC50 value of 8.18 μm. To further confirm the binding target, four compounds were selected to implement an HIV-1 RT inhibitory assay. In addition, preliminary structure-activity relationship (SAR) analysis and some predicted physicochemical properties of three active compounds Ia, Ih, and Ij were discussed in detail. Molecular docking studies were also carried out to investigate the binding modes of Ij and the lead compound GW678248 in the binding pocket of RT, which provided beneficial information for further rational design of non-nucleoside reverse transcriptase inhibitors.

Negishi coupling strategy of a repetitive two-step method for oligoarene synthesis

A novel repetitive two-step method for oligoarene synthesis, based on Negishi cross-coupling of zinciophenoxides or zinciopyridinoxides with aryl triflates and subsequent triflation of the hydroxy group, was developed. Reaction conditions were optimized for the preparation of the arylzinc compounds and the palladium-catalyzed cross-coupling step.