36747-99-6

Basic information

• Product Name: (2-chloro-1-ethoxyethyl)benzene
• Synonyms: (2-chloro-1-ethoxyethyl)benzene;(2-CHLORO-1-EHTOXYETHYL)BENZENE;1-Chloro-2-ethoxy-2-phenylethane;Ethyl(1-phenyl-2-chloroethyl) ether;β-Ethoxyphenethyl chloride
• CAS NO: 36747-99-6
• Molecular Formula: C10H13ClO
• Molecular Weight: 184.66262
• EINECS: 253-185-7
• Mol File: 36747-99-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 239°Cat760mmHg
• Flash Point: 104°C
• Appearance: /
• Density: 1.062g/cm³
• Vapor Pressure: 0.0633mmHg at 25°C
• Refractive Index: 1.506
• CAS DataBase Reference: (2-chloro-1-ethoxyethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: (2-chloro-1-ethoxyethyl)benzene(36747-99-6)
• EPA Substance Registry System: (2-chloro-1-ethoxyethyl)benzene(36747-99-6)

Safety Data

• Hazardous Substances Data: 36747-99-6(Hazardous Substances Data)

Usage

Description

(2-chloro-1-ethoxyethyl)benzene, also known as 1-(2-chloroethyl)ethoxybenzene, is an organic compound with the chemical formula C10H13ClO. It is a colorless to pale yellow liquid that serves as an intermediate in the production of pharmaceuticals and agrochemicals. This chemical is also utilized as a solvent in various industries.

Uses

Used in Pharmaceutical Industry:
(2-chloro-1-ethoxyethyl)benzene is used as an intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and medicines.
Used in Agrochemical Industry:
In the agrochemical sector, (2-chloro-1-ethoxyethyl)benzene is employed as an intermediate in the production of agrochemicals, which are essential for enhancing crop protection and yield.
Used as a Solvent in Various Industries:
(2-chloro-1-ethoxyethyl)benzene is utilized as a solvent across different industries due to its ability to dissolve a wide range of substances, facilitating various chemical processes and reactions.
Safety and Environmental Considerations:
It is crucial to handle (2-chloro-1-ethoxyethyl)benzene with care, as it can be harmful if ingested or inhaled and may cause skin and eye irritation upon contact. Moreover, it is considered hazardous to the environment, necessitating proper disposal to prevent contamination.

InChI:InChI=1/C10H13ClO/c1-2-12-10(8-11)9-6-4-3-5-7-9/h3-7,10H,2,8H2,1H3

Upstream product

• 100-42-5 styrene 
• 64-17-5 ethanol 
• 623-46-1 1,2-dichloro-2-ethoxyethane 

Downstream Products

• 91553-46-7 (β-ethoxy-phenethyl)-dimethyl-amine 
• 4152-26-5 1-Aethoxy-1-phenyl-2-(diaethylamino)-aethan 
• 76663-85-9 2-ethoxy-2-phenylethylamine 
• 6230-62-2 (1-ethoxyvinyl)benzene 

Relevant articles and documents

Cross-Linked Artificial Enzyme Crystals as Heterogeneous Catalysts for Oxidation Reactions

Designing systems that merge the advantages of heterogeneous catalysis, enzymology, and molecular catalysis represents the next major goal for sustainable chemistry. Cross-linked enzyme crystals display most of these essential assets (well-designed mesoporous support, protein selectivity, and molecular recognition of substrates). Nevertheless, a lack of reaction diversity, particularly in the field of oxidation, remains a constraint for their increased use in the field. Here, thanks to the design of cross-linked artificial nonheme iron oxygenase crystals, we filled this gap by developing biobased heterogeneous catalysts capable of oxidizing carbon-carbon double bonds. First, reductive O2 activation induces selective oxidative cleavage, revealing the indestructible character of the solid catalyst (at least 30 000 turnover numbers without any loss of activity). Second, the use of 2-electron oxidants allows selective and high-efficiency hydroxychlorination with thousands of turnover numbers. This new technology by far outperforms catalysis using the inorganic complexes alone, or even the artificial enzymes in solution. The combination of easy catalyst synthesis, the improvement of "omic" technologies, and automation of protein crystallization makes this strategy a real opportunity for the future of (bio)catalysis.

Trichloroisocyanuric Acid as a Cohalogenating Reagent: An Efficient Transformation of Alkenes into Chlorohydrins, β-Chloroethers and β-Chloroacetates

The preparation of diverse β-chloroethers, β-chloroacetates, and chlorohydrins is efficiently achieved under mild conditions by reaction of alkenes with trichloroisocyanuric acid (0.34 mol equiv) in alcohols (MeOH, EtOH, i-PrOH, t-BuOH), acetic acid or aqueous acetone, respectively.