36756-13-5Relevant articles and documents
Utilizing the chemiluminescence of 2-substituted-4,5-di(2-furyl)-1H- imidazole-H2O2-Cu2+ system for the determination of Cu2+
Zhang, Yihua,Kang, Jing,Zheng, Yumin,Han, Lu,Tang, Jieli,Wang, Shuaijun
, p. 376 - 382 (2011)
In the paper, 2,4,5-tri(2-furyl)-1H-imidazole (TFI) and 2-phenyl-4,5-di(2-furyl)-1H-imidazole (PDFI), were chosen to investigate chemiluminescence (CL) properties of 2-substituted-4,5-di(2-furyl)-1H- imidazoles. The directly oxidized CL of analytes by Hs
TMSOTf-catalyzed synthesis of trisubstituted imidazoles using hexamethyldisilazane as a nitrogen source under neat and microwave irradiation conditions
Asressu, Kesatebrhan Haile,Chan, Chieh-Kai,Wang, Cheng-Chung
, p. 28061 - 28071 (2021/09/15)
In the process of drug discovery and development, an efficient and expedient synthetic method for imidazole-based small molecules from commercially available and cheap starting materials has great significance. Herein, we developed a TMSOTf-catalyzed synthesis of trisubstituted imidazoles through the reaction of 1,2-diketones and aldehydes using hexamethyldisilazane as a nitrogen source under microwave heating and solvent-free conditions. The chemical structures of representative trisubstituted imidazoles were confirmed using X-ray single-crystal diffraction analysis. This synthetic method has several advantages including the involvement of mild Lewis acid, being metal- and additive-free, wide substrate scope with good to excellent yields and short reaction time. Furthermore, we demonstrate the application of the methodology in the synthesis of biologically active imidazole-based drugs.
CO2-assisted synthesis of non-symmetric α-diketones directly from aldehydes: Via C-C bond formation
Hirapara, Pradipbhai,Riemer, Daniel,Hazra, Nabanita,Gajera, Jignesh,Finger, Markus,Das, Shoubhik
supporting information, p. 5356 - 5360 (2017/11/22)
CO2-assisted various symmetric and non-symmetric α-diketones have been synthesized directly from the corresponding aldehydes using transition metal-free catalysts. This method can even be applied to synthesize pharmaceuticals directly from aldehydes. The crucial role of CO2 has been investigated in detail and the mechanism is proposed on the basis of experiments and DFT calculations.
Lewis acid catalyst free synthesis of substituted imidazoles in 2,2,2-trifluoroethanol
Khaksar, Samad,Alipour, Mandana
, p. 395 - 398 (2013/05/21)
A simple, inexpensive, environmentally friendly, and efficient route for the synthesis of highly substituted imidazoles by the condensation of 1,2-dicarbonyl compounds, aldehydes, and ammonium acetate using 2,2,2-trifluoroethanol as a solvent is described. The solvent can be readily separated from reaction products and recovered in excellent purity for direct reuse.
