36765-84-1

Basic information

• Product Name: 3-NITROPHENACYLAMINE HYDROCHLORIDE
• Synonyms: 2-AMINO-1-(3-NITROPHENYL)ETHAN-1-ONE HYDROCHLORIDE;3-NITROPHENACYLAMINE HYDROCHLORIDE;2-Amino-1-(3-nitrophenyl)ethan-1-oneHCl;2-AMINO-3'-NITROACETOPHENONE HYDROCHLORIDE;2-Amino-1-(3-nitrophenyl)ethan-1-one hydrochloride, 2-Amino-3'-nitroacetophenone hydrochloride;2-Amino-1-(3-nitrophenyl)ethanone hydrochloride;2-Amino-3'-nitroacetophenone HCl
• CAS NO: 36765-84-1
• Molecular Formula: C₈H₈N₂O₃*ClH
• Molecular Weight: 216.62
• Mol File: 36765-84-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 210-212°C (dec.)
• Boiling Point: 299.1°Cat760mmHg
• Flash Point: 134.7°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 0.00122mmHg at 25°C
• CAS DataBase Reference: 3-NITROPHENACYLAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-NITROPHENACYLAMINE HYDROCHLORIDE(36765-84-1)
• EPA Substance Registry System: 3-NITROPHENACYLAMINE HYDROCHLORIDE(36765-84-1)

Safety Data

• Statements: 34-37
• Safety Statements: 7/9-26-45
• RIDADR: 1759
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 36765-84-1(Hazardous Substances Data)

Usage

General Description

3-Nitrophenacylamine Hydrochloride is a chemical compound often used in scientific research and experimental works. Its chemical formula is C8H9ClN2O2. 3-NITROPHENACYLAMINE HYDROCHLORIDE appears mainly as a yellowish or light brown powder. As with most chemicals, it should be handled carefully due to the potential risks associated with exposure such as skin irritation or serious eye irritation. In laboratory settings, this compound is often used in organic reactions for its unique physical and chemical properties. No absolute evidence specifies its wide use in industries like pharmaceuticals, agriculture, or cosmetics. Like most laboratory chemicals, it needs to be handled and stored properly following Material Safety Data Sheet (MSDS) guidelines.

InChI:InChI=1/C8H8N2O3/c9-5-8(11)6-2-1-3-7(4-6)10(12)13/h1-4H,5,9H2/p+1

Upstream product

• 7478-10-6 1-(m-nitrophenyl)-3,5,7-triaza-1-azoniaadamantane bromide 
• 2227-64-7 3'-nitro-2-bromoacetophenone 
• 121-89-1 3-Nitroacetophenone 
• 98-86-2 acetophenone 

Downstream Products

• 137965-23-2 α-(dichloroacetamido)-m-nitroacetophenone 
• 90490-70-3 2-(2,5-Dimethyl-pyrrol-1-yl)-1-(3-nitro-phenyl)-ethanone 
• 138125-72-1 2-(dichloroacetamido)-1-(m-nitrophenyl)-1,3-propanediol 
• 137965-24-3 α-(dichloroacetamido)-β-hydroxy-m-nitropropiophenone 
• 137965-25-4 2-(dichloroacetamido)-2-(m-nitrobenzoyl)-1,3-propanediol 
• 137965-27-6 2,2-Dichloro-N-[(4R,5R)-2,2-dimethyl-4-(3-nitro-phenyl)-[1,3]dioxan-5-yl]-acetamide 
• 859481-13-3 5‐(3‐nitrophenyl)‐1,3‐thiazole 
• 1350614-56-0 C₁₃H₁₆N₂O₅ 
• 1456532-28-7 2-amino-1-(3-nitrophenyl)ethan-1-one thiosemicarbazone 
• 1541243-61-1 C₂₅H₂₆N₄O₆ 
• 1541243-62-2 (S)-tert-butyl 2-(3-(5-(3-aminophenyl)oxazol-2-yl)phenylcarbamoyl)pyrrolidine-1-carboxylate 
• 1541243-63-3 C₃₅H₄₃N₅O₇ 
• 1541243-65-5 (2S)-1-[(2R)-2-(dimethylamino)-2-phenylacetyl]-N-[3-(2-{3-[(2S)-1-[(2R)-2-(dimethylamino)-2-phenylacetyl]pyrrolidine-2-amido]phenyl}-1,3-oxazol-5-yl)phenyl]pyrrolidine-2-carboxamide 
• 1541243-60-0 (S)-tert-butyl 2-(3-(2-(3-nitrophenyl)-2-oxoethylcarbamoyl)phenylcarbamoyl)pyrrolidine-1-carboxylate 

Relevant articles and documents

Design, synthesis and biological evaluation of new aryl thiosemicarbazone as antichagasic candidates

The present work reports on the synthesis, biological assaying and docking studies of a series of 12 aryl thiosemicarbazones, which were planned to act over two main enzymes, cruzain and trypanothione reductase. These enzymes are used as targets of trypanocidal activity in Chagas disease control with a minimal mutagenic profile. Three p-nitroaromatic thiosemicarbazones showed high activity against Trypanosoma cruzi in in vitro assays (IC50 57 μM), and no mutagenic profile was observed in micronucleous tests. Although the in vitro inhibition test showed that 10-μM doses of eight compounds inhibited cruzain activity, no correlation was found between cruzain inhibition and trypanocidal activity.

Thiadizines

Novel heterocyclic compounds of the formula: STR1 wherein either X is --CR1 R2 -- and Y is oxygen, sulphur or --NR3, wherein R1, R2 and R3, which may be the same or different, each is hydrogen or alkyl of up to 4 carbon atoms; or X is oxygen, sulphur or --NH-- and Y is --CH2 --; wherein R4 and R5, which may be the same or different, each is hydrogen, cyano, nitro, amino or hydroxy, or alkylthio of up to 4 carbon atoms, or has various other meanings defined in claim 1, provided that R4 and R5 are not both hydrogen; or wherein R4 and R5 are joined together such that with the benzene ring A they form a benzheterocyclic ring as defined in claim 1; and therein the benzene ring A may optionally bear one or more further substituents; or a salt thereof where appropriate. These compounds possess cardiotonic properties, and some of them possess peripheral vasodilator properties, and they are useful for the treatment of acute or chronic heart failure. Representative of the compounds is N,N-dimethyl-p-(5,6-dihydro-5-oxo-4H-1,3,4-thiadiazin-2-yl)benzamide. Also disclosed are processes for the manufacture of the compounds and pharmaceutical compositions containing them.