36783-81-0

Basic information

• Product Name: 1H-Imidazole, 1-methyl-2-(4-nitrophenyl)-4,5-diphenyl-
• CAS NO: 36783-81-0
• Molecular Formula: C22H17N3O2
• Molecular Weight: 355.396
• Mol File: 36783-81-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1H-Imidazole, 1-methyl-2-(4-nitrophenyl)-4,5-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole, 1-methyl-2-(4-nitrophenyl)-4,5-diphenyl-(36783-81-0)
• EPA Substance Registry System: 1H-Imidazole, 1-methyl-2-(4-nitrophenyl)-4,5-diphenyl-(36783-81-0)

Safety Data

• Hazardous Substances Data: 36783-81-0(Hazardous Substances Data)

Upstream product

• 631-61-8 ammonium acetate 
• 555-16-8 4-nitrobenzaldehdye 
• 134-81-6 benzil 
• 74-89-5 methylamine 
• 5496-39-9 2-(4-nitrophenyl)-4,5-diphenyl-1H-imidazole 
• 74-88-4 methyl iodide 

Downstream Products

• 918664-36-5 1-methyl-2-(4-aminophenyl)-4,5-diphenyl-1H-imidazole 

Relevant articles and documents

Synthesis and biological evaluation of 1,2,4,5-tetrasubstituted imidazoles

Tetrasubstituted imidazoles were synthesized in high yields via the four-component reaction of aromatic aldehydes, amines, substituted benzils and ammonium acetate catalyzed by a porous CeO2 nanorod. Their anti-cancer activities on the Huh-7 hepatocellular carcinoma cell and antibacterial activities on four bacterial species (wild-type Escherichia coli, wild-type Staphylococcus aureus, Pseudomonas aeruginosa PAM1032 and Escherichia coli-NMD-1) in vitro were evaluated. One compound (5p) was screened out because of its high inhibition rate on all four bacterials at 100 μg/mL. Three products (5p, 5t and 5y) showed a high inhibition rate on the Huh-7 hepatocellular carcinoma cell at 10 μg/mL. The results indicated their potential in new drug development.

Synthesis of 2-substituted-N-[4-(1-methyl-4,5-diphenyl-1H-imidazole-2-yl) phenyl] acetamide derivatives and evaluation of theiranticancer activity

In the present study 18 novel imidazole-(benz)azole and imidazoleepiperazine derivatives were synthesized in order to investigate their probable anticancer activity. The structures of the compounds were confirmed by IR,1H NMR and EI-MS spectral data. Cytotoxicity (MTT),analysis of DNA synthesis and detection of apoptotic DNA assays were applied to determine anticancer activity of the compounds against colon (HT-29) and breast (MCF-7) carcinoma cell lines. Most of the compounds,showed greater activity against HT-29 cells than MCF-7 cells. Some of them indicated considerable cytotoxicity against both of the carcinogenic cell lines. However,their inhibitory activity on DNA synthesis was relatively poor. Anticancer activity screening results revealed that 11,12 and 13 were the most active compounds in the series. They exhibited significant cytotoxicity against both of the carcinogenic cell lines and caused DNA fragmentation of the HT-29 cells.

New class of imidazoles incorporated with thiophenevinyl conjugation pathway for robust nonlinear optical chromophores

A new series of thermally stable heterocyclic imidazole-based nonlinear optical chromophores has been developed. These chromophores possess a thiophene based stilbene conjugation pathway with a nitro acceptor group attached to the phenyl end. This feature leads to robust chromopores with high thermal stability and enhanced molecular nonlinearity.