36796-46-0Relevant articles and documents
Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain
Vardanyan, Ruben,Vijay, Gokhale,Nichol, Gary S.,Liu, Lu,Kumarasinghe, Isuru,Davis, Peg,Vanderah, Todd,Porreca, Frank,Lai, Josephine,Hruby, Victor J.
experimental part, p. 5044 - 5053 (2009/12/04)
Acids 9a-f as possible bivalent ligands designed as a structural combination of opioid μ-agonist (Fentanyl) and NSAID (Indomethacin) activities and produced compounds which were tested as analgesics. The obtained series of compounds exhibits low affinity and activity both at opioid receptors and as cyclooxygenase (COX) inhibitors. One explanation of the weak opioid activity could be stereochemical peculiarities of these bivalent compounds which differ significantly from the fentanyl skeleton. The absence of significant COX inhibitory properties could be explained by the required substitution of an acyl fragment in the indomethacin structure for 4-piperidyl.
A simple and convenient route to 1,2,3,4,5,6,7,8-octahydro-1,6- naphthyridines
Gaidarova, Elena L.,Borisenko, Anatoly A.,Chumakov, Taras I.,Mel'nikov, Andrey V.,Orlov, Ivan S.,Grishina, Galina V.
, p. 7767 - 7770 (2007/10/03)
A simple and convenient synthetic approach to the new series of 1,2,3,4,5,6,7,8-octahydro-1,6-naphthyridines 1a-j has been developed. This was achieved via a one-pot process combining metalated 4-piperidinonimine alkylation and intramolecular cyclization.
