36799-48-1

Basic information

• Product Name: 3,4-dimethylphenylglyoxylic acid
• Synonyms: 3,4-dimethylphenylglyoxylic acid
• CAS NO: 36799-48-1
• Molecular Weight: 178.188
• Mol File: 36799-48-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3,4-dimethylphenylglyoxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-dimethylphenylglyoxylic acid(36799-48-1)
• EPA Substance Registry System: 3,4-dimethylphenylglyoxylic acid(36799-48-1)

Safety Data

• Hazardous Substances Data: 36799-48-1(Hazardous Substances Data)

Upstream product

• 3637-01-2 3,4-dimethylacetophenone 
• 71-43-2 benzene 

Downstream Products

• 65614-75-7 3,4-dimethyl-deoxybenzoin 
• 80120-32-7 ethyl 2-(3,4-dimethylphenyl)-2-oxoacetate 
• 1339876-61-7 (2-benzoylphenyl)(3,4-dimethylphenyl)methanone 

Relevant articles and documents

Photoredox Catalysis Enables Decarboxylative Cyclization with Hypervalent Iodine(III) Reagents: Access to 2,5-Disubstituted 1,3,4-Oxadiazoles

A novel approach to 2,5-disubstituted 1,3,4-oxadiazoles derivatives via a decarboxylative cyclization reaction by photoredox catalysis between commercially available α-oxocarboxylic acids and hypervalent iodine(III) reagent is described. This powerful transformation involves the coupling reaction between two different kinds of radical species and the formation of C-N and C-O bonds.

Selective photoredox decarboxylation of α-ketoacids to allylic ketones and 1,4-dicarbonyl compounds dependent on cobaloxime catalysis

A photoredox/cobaloxime co-catalyzed coupling reaction of α-ketoacids and methacrylates to obtain allylic ketones is described. Without the cobaloxime catalyst, 1,4-dicarbonyl compounds are generated. The cobaloxime catalyst enables dehydrogenation to generate the formation of new olefins. The generality, good substrate scope and mild conditions are good features in the photoredox/cobaloxime catalysis protocol, and this method will provide new opportunities for the functionalization of more olefins.

Pd(OAc)2-Catalyzed Asymmetric Hydrogenation of α-Iminoesters

An efficient Pd(OAc)2-catalyzed asymmetric hydrogenation of α-iminoesters was realized for the first time at 1 atm hydrogen pressure and room temperature. Pd(OAc)2, a less expensive Pd salt with low toxicity, was found to be the most suitable catalyst precursor rather than Pd(TFA)2 which is usually the catalyst of choice for homogeneous asymmetric hydrogenation. The chiral α-arylglycine fragments are widely found in many chiral products and bioactive molecules.