368-05-8

Basic information

• Product Name: 1,3-bis(2-fluorophenyl)thiourea
• Synonyms: 1,3-Bis(2-fluorophenyl)thiourea; N,N'-bis(2-fluorophenyl)thiourea; thiourea, N,N'-bis(2-fluorophenyl)-
• CAS NO: 368-05-8
• Molecular Formula: C₁₃H₁₀F₂N₂S
• Molecular Weight: 264.2937
• Mol File: 368-05-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 334.6°C at 760 mmHg
• Flash Point: 156.2°C
• Density: 1.419g/cm³
• Vapor Pressure: 0.000126mmHg at 25°C
• Refractive Index: 1.704
• CAS DataBase Reference: 1,3-bis(2-fluorophenyl)thiourea(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-bis(2-fluorophenyl)thiourea(368-05-8)
• EPA Substance Registry System: 1,3-bis(2-fluorophenyl)thiourea(368-05-8)

Safety Data

• Hazardous Substances Data: 368-05-8(Hazardous Substances Data)

Usage

Type of compound

Thiourea

Presence of fluorine

Yes

Potential applications

a. Organic synthesis
b. Reagent in chemical reactions
c. Pharmaceuticals
d. Agrochemicals
e. Material science

Diverse reactivity

Yes

Biological activities

Yes

Current research

Investigating potential uses and properties in various fields

Upstream product

• 75-15-0 carbon disulfide 
• 348-54-9 2-Fluoroaniline 
• 38985-64-7 o-fluorophenyl isothiocyanate 

Downstream Products

• 7639-58-9 N-(2-fluoro-phenyl)-oxalomonoimidic acid-(2-fluoro-anilide)-nitrile 
• 51964-14-8 3-(2-fluorophenyl)-2-(2-fluorophenylimino)-1,3-thiazolidine-4-one 
• 73219-55-3 3-(2-fluoro-phenyl)-thiazolidine-2,4-dione 
• 349-19-9 N-(2-fluoro-phenyl)-2-thio-oxalomonoimidic acid-1-(2-fluoro-anilid)-2-amide 
• 1017535-53-3 1-acetyl-1,3-di-(o-fluorophenyl)urea 

Relevant articles and documents

Novel non-peptidic small molecule inhibitors of secreted aspartic protease 2 (SAP2) for the treatment of resistant fungal infections

Targeting secreted aspartic protease 2 (SAP2), a kind of virulence factor, represents a new strategy for antifungal drug discovery. In this report, the first-generation of small molecule SAP2 inhibitors was rationally designed and optimized using a structure-based approach. In particular, inhibitor 23h was highly potent and selective and showed good antifungal potency for the treatment of resistant Candida albicans infections.

Syntheses, structures and bioactivities of fluorine-containing phenylimino-thia(oxa)zolidine derivatives as agricultural bioregulators

From insight into the structure of trehazolin as trehalase inhibitor, six series of fluorine-containing phenylimino-thiazolidines (oxazolidines) derivatives were designed and prepared through a convenient synthesis of fluoroaryl isothiocyanate and a one-pot facile synthesis in high yield of fluorophenyl aminobenzoxazoles by cyclodesulfurization. The structures of the target compounds were confirmed with using IR, NMR, MS and elemental analysis. Their X-ray crystal analysis suggested that there were novel intermolecular (sp2CF?H3C) and intramolecular (sp 2CF?HN) hydrogen bonds between the fluorine atom on benzene ring and hydrogen atom of methyl group or amino group on five-membered heterocycle. Their fungicidal activities against Rhizoctonia solani and Pyricuraria oryzae at 100 ppm were determined. From insight into the structure of trehazolin as trehalase inhibitor, six series of fluorine-containing phenylimino-thiazolidines (oxazolidines) derivatives were designed and prepared through a convenient synthesis of fluoroaryl isothiocyanate and a one-pot facile synthesis in high yield of fluorophenyl aminobenzoxazoles by cyclodesulfurization. The structures of the target compounds were confirmed with using IR, NMR, MS and elemental analysis. Their X-ray crystal analysis suggested that there were novel intermolecular (sp2CF?H 3C) and intramolecular (sp2CF?HN) hydrogen bonds between the fluorine atom on benzene ring and hydrogen atom of methyl group or amino group on five-membered heterocycle. Their fungicidal activities against Rhizoctonia solani and Pyricuraria oryzae at 100 ppm were determined. fx1

4 Thiazolidinones XVIII. 3 aryl 2 arylimino 4 thiazolidinones derived from sym diarylthioureas

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