36838-71-8 Usage
Description
4-Methylenetetrahydro-2H-pyran is an organic compound belonging to the class of heterocyclic compounds, specifically a tetrahydro-2H-pyran derivative. It is characterized by the presence of a methylene group (CH2) adjacent to the oxygen atom in the pyran ring, which confers unique chemical properties and reactivity to the molecule.
Uses
Used in Pharmaceutical Industry:
4-Methylenetetrahydro-2H-pyran is used as a key intermediate in the synthesis of various griseofulvin derivatives. These derivatives exhibit anti-inflammatory properties and are particularly effective in treating conditions related to the central nervous system. 4-Methylenetetrahydro-2H-pyran's unique structure allows for the development of new therapeutic agents with potential applications in managing inflammation and pain associated with neurological disorders.
Used in Chemical Synthesis:
In addition to its pharmaceutical applications, 4-Methylenetetrahydro-2H-pyran serves as a versatile building block in the synthesis of a wide range of organic compounds. Its reactivity and structural features make it a valuable component in the creation of complex molecules for various industries, including materials science, agrochemicals, and specialty chemicals. 4-Methylenetetrahydro-2H-pyran's ability to participate in a variety of chemical reactions, such as electrophilic and nucleophilic substitutions, as well as ring-opening and ring-closing processes, contributes to its utility in synthetic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 36838-71-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,8,3 and 8 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 36838-71:
(7*3)+(6*6)+(5*8)+(4*3)+(3*8)+(2*7)+(1*1)=148
148 % 10 = 8
So 36838-71-8 is a valid CAS Registry Number.
36838-71-8Relevant articles and documents
EXPERIMENTAL STUDIES OF THE ANOMERIC EFFECT. PART I. 2-SUBSTITUTED TETRAHYDROPYRANS.
Booth, Harold,Kheidhair, Kheidhair A.,Readshaw, Simon A.
, p. 4699 - 4724 (2007/10/02)
Variable temperature (1)H and (13)C n.m.r. studies in CFCl3/CDCl3 of equilibria in 2-substituted- and 2-substituted-4-methyl-tetrahydropyranes have given conformational enthalpy differences and conformational entropy differences for chloro, methoxy, hydroxy and methylamino substituents.For ΔHoa->e, the values obtained, in kcal /mol, were 1.67 (Cl), 0.03 (OCH3), -0.63 (OH) and -1.75 (NHCH3); for ΔSoa->e the values obtained, in cal K-1mol-1 were -1.69 (Cl), -2.52 (OCH3), -2.50 (OH) and -0.60 (NHCH3).The trend in ΔHo values confirms the importance of antiperiplanar n-?* stabilisation as a contributor to the explanation of the anomeric effect, and supports a suggestion that endo- and exo-anomeric effects which occur in the same conformation are competitive.A variable temperature (13)C n.m.r. study of (Me-(13)C)-4-methyl-tetrahydropyran in CD2Cl2 has given a conformational enthalpy difference (ΔHoa->e) of -1.86 kcal/mol and a conformational entropy difference (ΔSoa->e) of -0.07 cal K-1mol-1 for a methyl substituent at the 4-position of a tetrahydropyran.