368426-31-7

Basic information

• Product Name: 2-[3-(2,3-dihydro-benzofuran-5-sulfonylamino)-2-oxo-azepan-1-yl]-N-[4-(N-hydroxycarbamimidoyl)-benzyl]-acetamide
• Synonyms: 2-[3-(2,3-dihydro-benzofuran-5-sulfonylamino)-2-oxo-azepan-1-yl]-N-[4-(N-hydroxycarbamimidoyl)-benzyl]-acetamide
• CAS NO: 368426-31-7
• Molecular Weight: 515.59
• Mol File: 368426-31-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[3-(2,3-dihydro-benzofuran-5-sulfonylamino)-2-oxo-azepan-1-yl]-N-[4-(N-hydroxycarbamimidoyl)-benzyl]-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[3-(2,3-dihydro-benzofuran-5-sulfonylamino)-2-oxo-azepan-1-yl]-N-[4-(N-hydroxycarbamimidoyl)-benzyl]-acetamide(368426-31-7)
• EPA Substance Registry System: 2-[3-(2,3-dihydro-benzofuran-5-sulfonylamino)-2-oxo-azepan-1-yl]-N-[4-(N-hydroxycarbamimidoyl)-benzyl]-acetamide(368426-31-7)

Safety Data

• Hazardous Substances Data: 368426-31-7(Hazardous Substances Data)

Upstream product

• 368426-10-2 [(S)-3-(2,3-Dihydro-benzofuran-5-sulfonylamino)-2-oxo-azepan-1-yl]-acetic acid benzyl ester 
• 115010-11-2 2,3-dihydrobenzofuran-5-sulfonyl chloride 
• 21568-87-6 2-aminocaprolactam 
• 93961-02-5 (S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-oxo-hexahydro-1H-azepine-1-acetic acid,phenylmethyl ester 
• 93961-03-6 (S)-3-Amino-2-oxo-hexahydro-1H-azepine-1-acetic acid, phenylmethyl ester 
• 17201-43-3 4-cyanobenzyl bromide 
• 76944-95-1 tert-butyl N-[(3S)-2-oxoazepan-3-yl]carbamate 
• 84466-87-5 4-(azidomethyl)benzonitrile 
• 10406-25-4 4-aminobenzyl cyanide 
• 328552-93-8 4-(aminomethyl)-N-hydroxybenzene-1-carboximidamide 
• 368426-11-3 [(S)-3-(2,3-Dihydro-benzofuran-5-sulfonylamino)-2-oxo-azepan-1-yl]-acetic acid 

Relevant articles and documents

Novel, potent non-covalent thrombin inhibitors incorporating P3-lactam scaffolds

Evolution of P1-argininal inhibitor prototypes led to a series of non-covalent P3-7-membered lactam inhibitors 1a-w, featuring novel peptidomimetic units that probe each of the S1, S2, and S3 specificity pockets of thrombin. Rigid P1-arginine surrogates possessing a wide range of basicity (calcd pKa's～neutral-14) were surveyed. The design, synthesis, and biological activity of these targets are presented.