368426-43-1

Basic information

• Product Name: [4-({2-[3-(2,3-dihydro-benzofuran-5-sulfonylamino)-2-oxo-azepan-1-yl]-acetylamino}-methyl)-cyclohexyl]-carbamic acid tert-butyl ester
• Synonyms: [4-({2-[3-(2,3-dihydro-benzofuran-5-sulfonylamino)-2-oxo-azepan-1-yl]-acetylamino}-methyl)-cyclohexyl]-carbamic acid tert-butyl ester
• CAS NO: 368426-43-1
• Molecular Weight: 578.73
• Mol File: 368426-43-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [4-({2-[3-(2,3-dihydro-benzofuran-5-sulfonylamino)-2-oxo-azepan-1-yl]-acetylamino}-methyl)-cyclohexyl]-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [4-({2-[3-(2,3-dihydro-benzofuran-5-sulfonylamino)-2-oxo-azepan-1-yl]-acetylamino}-methyl)-cyclohexyl]-carbamic acid tert-butyl ester(368426-43-1)
• EPA Substance Registry System: [4-({2-[3-(2,3-dihydro-benzofuran-5-sulfonylamino)-2-oxo-azepan-1-yl]-acetylamino}-methyl)-cyclohexyl]-carbamic acid tert-butyl ester(368426-43-1)

Safety Data

• Hazardous Substances Data: 368426-43-1(Hazardous Substances Data)

Upstream product

• 177583-27-6 tert-butyl ((1r,4r)-4-(aminomethyl)cyclohexyl)carbamate 
• 368426-11-3 [(S)-3-(2,3-Dihydro-benzofuran-5-sulfonylamino)-2-oxo-azepan-1-yl]-acetic acid 
• 76944-95-1 tert-butyl N-[(3S)-2-oxoazepan-3-yl]carbamate 
• 93961-03-6 (S)-3-Amino-2-oxo-hexahydro-1H-azepine-1-acetic acid, phenylmethyl ester 
• 368426-10-2 [(S)-3-(2,3-Dihydro-benzofuran-5-sulfonylamino)-2-oxo-azepan-1-yl]-acetic acid benzyl ester 
• 115010-11-2 2,3-dihydrobenzofuran-5-sulfonyl chloride 
• 21568-87-6 2-aminocaprolactam 
• 93961-02-5 (S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-oxo-hexahydro-1H-azepine-1-acetic acid,phenylmethyl ester 

Relevant articles and documents

Novel, potent non-covalent thrombin inhibitors incorporating P3-lactam scaffolds

Evolution of P1-argininal inhibitor prototypes led to a series of non-covalent P3-7-membered lactam inhibitors 1a-w, featuring novel peptidomimetic units that probe each of the S1, S2, and S3 specificity pockets of thrombin. Rigid P1-arginine surrogates possessing a wide range of basicity (calcd pKa's～neutral-14) were surveyed. The design, synthesis, and biological activity of these targets are presented.