3685-55-0 Usage
Description
2-Hydroxymuconic acid is a chemical compound derived from muconic acid, which is an intermediate in the degradation of aromatic compounds such as benzene and toluene. It is produced in the body as a metabolite of the aromatic amino acid tyrosine and can also be found as a byproduct of microbial metabolism in the environment.
Uses
Used in Environmental Monitoring:
2-Hydroxymuconic acid is used as a biomarker for exposure to benzene and other aromatic hydrocarbons, helping to assess the level of environmental contamination and potential health risks.
Used in Medical Research:
2-Hydroxymuconic acid is used as a biomarker in medical research to study the effects of exposure to aromatic hydrocarbons on human health and to develop methods for early detection and prevention of related diseases.
Used in Chemical Synthesis:
2-Hydroxymuconic acid is used as a building block for the synthesis of polymers and other organic compounds, contributing to the development of new materials and products in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 3685-55-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,6,8 and 5 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 3685-55:
(6*3)+(5*6)+(4*8)+(3*5)+(2*5)+(1*5)=110
110 % 10 = 0
So 3685-55-0 is a valid CAS Registry Number.
InChI:InChI=1/C6H6O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3,8-9H,(H,10,11)/b2-1+
3685-55-0Relevant articles and documents
Metabolism of 4-amino-3-hydroxybenzoic acid by Bordetella sp. strain 10d: A different modified meta-cleavage pathway for 2-aminophenols
Orii, Chika,Takenaka, Shinji,Murakami, Shuichiro,Aoki, Kenji
, p. 2653 - 2661 (2007/10/03)
Bordetella sp. strain 10d metabolizes 4-amino-3-hydroxybenzoic acid via 2-hydroxymuconic 6-semialdehyde. Cell extracts from 4-amino-3-hydroxybenzoate- grown cells showed high NAD+-dependent 2-hydroxymuconic 6-semialdehyde dehydrogenase, 4-oxalocrotonate tautomerase, 4-oxalocrotonate decarboxylase, and 2-oxopent-4-enoate hydratase activities, but no 2-hydroxymuconic 6-semialdehyde hydrolase activity. These enzymes involved in 4-amino-3-hydroxybenzoate metabolism were purified and characterized. When 2-hydroxymuconic 6-semialdehyde was used as substrate in a reaction mixture containing NAD+ and cell extracts from 4-amino-3-hydroxybenzoate-grown cells, 4-oxalocrotonic acid, 2-oxopent-4-enoic acid, and 4-hydroxy-2-oxovaleric acid were identified as intermediates, and pyruvic acid was identified as the final product. A complete pathway for the metabolism of 4-amino-3-hydroxybenzoic acid in strain 10d is proposed. Strain 10d metabolized 2-hydroxymuconic 6-semialdehyde derived from 4-amino-3-hydroxybenzoic acid via a dehydrogenative route, not via a hydrolytic route. This proposed metabolic pathway differs considerably from the modified meta-cleavage pathway of 2-aminophenol and those previously reported for methyl- and chloroderivatives.
