36855-81-9

Basic information

• Product Name: N-(2-methylphenyl)-4-nitrobenzamide
• Synonyms: benzamide, N-(2-methylphenyl)-4-nitro-; N-(2-Methylphenyl)-4-nitrobenzamide
• CAS NO: 36855-81-9
• Molecular Formula: C₁₄H₁₂N₂O₃
• Molecular Weight: 256.2567
• Mol File: 36855-81-9.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 348.7°C at 760 mmHg
• Flash Point: 164.7°C
• Density: 1.304g/cm³
• Vapor Pressure: 4.95E-05mmHg at 25°C
• Refractive Index: 1.656
• CAS DataBase Reference: N-(2-methylphenyl)-4-nitrobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-methylphenyl)-4-nitrobenzamide(36855-81-9)
• EPA Substance Registry System: N-(2-methylphenyl)-4-nitrobenzamide(36855-81-9)

Safety Data

• Hazardous Substances Data: 36855-81-9(Hazardous Substances Data)

Upstream product

• 122-04-3 4-nitro-benzoyl chloride 
• 95-53-4 o-toluidine 
• 62-23-7 4-nitro-benzoic acid 

Downstream Products

• 888-78-8 4-Amino-benz-o-toluidid 

Relevant articles and documents

Mild and efficient palladium-catalyzed direct trifluoroethylation of aromatic systems by C-H activation

The introduction of trifluoroalkyl groups into aromatic molecules is an important transformation in the field of organic and medicinal chemistry. However, the direct installation of fluoroalkyl groups onto aromatic molecules still represents a challenging and highly demanding synthetic task. Herein, a simple trifluoroethylation process that relies on the palladium-catalyzed C-H activation of aromatic compounds is described. With the utilization of a highly active trifluoroethyl(mesityl)iodonium salt, the developed catalytic method enables the first highly efficient and selective trifluoroethylation of aromatic compounds. The robust catalytic procedure provides the desired products in up to 95 % yield at 25 °C in 1.5 to 3 hours and tolerates a broad range of functional groups. The utilization of hypervalent reagents opens new synthetic possibilities for direct alkylations and fluoroalkylations in the field of transition-metal-catalyzed C-H activation.

Transformation of thioamide compounds to corresponding amides using 12-Tungstosilicic acid

12-Tungstosilicic acid (H4SiW12O40) is applied for the conversion of a series of thioamides to their corresponding oxo analogues in excellent yields in acetonitrile. In the case of thioketones, no reaction is observed under these conditions. The reusability of the catalyst also is investigated.

A mild and convenient method for conversion of thioamides to their corresponding amides using acidified wet silica-supported permanganate under solvent-free conditions

A mild and efficient method for conversion of thioamides to their corresponding amides is reported. A series of thioamides are transformed to their corresponding carbonyl compounds in good to excellent yields by acidified wet silica-supported permanganate under solid phase conditions.