368890-20-4 Usage
Description
5-(Difluoromethoxy)-2[[(4-chloro-3-methoxy-2-pyridinyl)methyl]-thio]-1H-benzimidazole is a chemical compound with a complex structure that features a benzimidazole core, a difluoromethoxy group, and a thio-linked pyridinylmethyl moiety. 5-(Difluoromethoxy)-2[[(4-chloro-3-methoxy-2-pyridinyl)methyl]-thio]-1H-benzimidazole is characterized by its potential applications in the pharmaceutical industry, particularly in the development of isotopically substituted drugs for treating various medical conditions.
Uses
Used in Pharmaceutical Industry:
5-(Difluoromethoxy)-2[[(4-chloro-3-methoxy-2-pyridinyl)methyl]-thio]-1H-benzimidazole is used as a key intermediate in the synthesis of isotopically substituted pantoprazole, a proton pump inhibitor (PPI) that is commonly prescribed for the treatment of gastrointestinal disorders such as gastroesophageal reflux disease (GERD), peptic ulcers, and other acid-related conditions. The use of this compound in the preparation of isotopically substituted pantoprazole allows for the development of drugs with improved pharmacokinetic properties, enhanced stability, and potentially better therapeutic outcomes for patients suffering from these disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 368890-20-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,6,8,8,9 and 0 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 368890-20:
(8*3)+(7*6)+(6*8)+(5*8)+(4*9)+(3*0)+(2*2)+(1*0)=194
194 % 10 = 4
So 368890-20-4 is a valid CAS Registry Number.
InChI:InChI=1/C15H12ClF2N3O2S/c1-22-13-9(16)4-5-19-12(13)7-24-15-20-10-3-2-8(23-14(17)18)6-11(10)21-15/h2-6,14H,7H2,1H3,(H,20,21)
368890-20-4Relevant articles and documents
ISOTOPICALLY SUBSTITUTED PANTOPRAZOLE
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Page/Page column 15-16, (2008/06/13)
The invention relates to compounds of formula 1 and to medicaments comprising these compounds, further to intermediates of formula 2 and 3.
A process for the preparation of pantoprazole and salts thereof
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Page/Page column 5, (2010/02/11)
A process for the preparation of pantoprazole and the salts thereof, comprising the reaction of a mercaptoimidazole with a picoline, to give a 2-pyridinyl-methylsulfinyl-2-benzimidazole intermediate, the oxidation thereof with ε-phthalimidoperhexanoic acid and the subsequent methoxylation.
