36897-65-1

Basic information

• Product Name: 4(3H)-Quinazolinone, 3-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-
• CAS NO: 36897-65-1
• Molecular Formula: C16H9ClN4OS
• Molecular Weight: 340.793
• Mol File: 36897-65-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4(3H)-Quinazolinone, 3-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(3H)-Quinazolinone, 3-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-(36897-65-1)
• EPA Substance Registry System: 4(3H)-Quinazolinone, 3-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-(36897-65-1)

Safety Data

• Hazardous Substances Data: 36897-65-1(Hazardous Substances Data)

Upstream product

• 19555-60-3 bis-4H-3,1-benzoxazine-4-one 
• 28004-62-8 2-amino-5-(4-chlorophenyl)-1,3,4-thiadiazole 
• 64-18-6 formic acid 
• 118-92-3 anthranilic acid 
• 3342-77-6 N-formylanthranilic acid 

Relevant articles and documents

A novel route to the niementowski reaction

The Niementowski reaction has been extended to synthesize 3-substituted/2,3-disubstituted-4(3H)quinazolinones instead of the 2-substituted derivatives. The methodology is environmentally benign and completely eliminates the need of solvent from the reaction. Neat reactants were cyclocondensed under microwaves to afford, in good yield, the desired product in less irradiation time as compared to the classical technique. The reaction time was reduced from hours to minutes along with yield enhancement. The rate enhancement and high yield are attributed to the coupling of solvent-free conditions with microwaves.