36944-82-8

Basic information

• Product Name: (2-methylindolizin-3-yl)(phenyl)methanone
• CAS NO: 36944-82-8
• Molecular Formula: C₁₆H₁₃NO
• Molecular Weight: 235.2805
• Mol File: 36944-82-8.mol
• Article Data: 5

Chemical Properties

• Density: 1.11g/cm³
• Refractive Index: 1.608
• CAS DataBase Reference: (2-methylindolizin-3-yl)(phenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (2-methylindolizin-3-yl)(phenyl)methanone(36944-82-8)
• EPA Substance Registry System: (2-methylindolizin-3-yl)(phenyl)methanone(36944-82-8)

Safety Data

• Hazardous Substances Data: 36944-82-8(Hazardous Substances Data)

Usage

Description

(2-methylindolizin-3-yl)(phenyl)methanone is a chemical compound with the molecular formula C19H15NO. It is a ketone derivative consisting of a phenyl group attached to a 2-methylindolizin-3-yl group. (2-methylindolizin-3-yl)(phenyl)methanone belongs to the class of organic compounds known as indolizines, which are polycyclic compounds containing an indolizine moiety, a bicyclic compound with a six-member ring fused to a five-member ring. The presence of the ketone group in (2-methylindolizin-3-yl)(phenyl)methanone makes it potentially useful in various chemical reactions and synthesis processes.

Uses

Further research and studies are necessary to fully understand the properties and potential applications of (2-methylindolizin-3-yl)(phenyl)methanone. Its unique structure and the presence of the ketone group may allow it to be used in various chemical reactions and synthesis processes. However, specific applications and industries have not been identified in the provided materials.

Upstream product

• 768-18-3 2-methylindolizine 
• 98-88-4 benzoyl chloride 
• 96206-84-7 1-(2-Oxo-2-phenyl-ethyl)-2-prop-1-ynyl-pyridinium; bromide 
• 40925-52-8 2-(prop-1-yn-1-yl)pyridine 
• 70-11-1 α-bromoacetophenone 
• 110-86-1 pyridine 
• 107-93-7 (E)-but-2-enoic acid 
• 98-86-2 acetophenone 
• 16883-69-5 N-phenacylpyridinium bromide 
• 220961-10-4 ((2-bromo-2-propenyl)sulfonyl)benzene 
• 23451-62-9 dimethyl(prop-2-yn-1-yl)sulfonium bromide 

Downstream Products

• 80413-24-7 3-benzyl-2-methyl-indolizine 

Relevant articles and documents

A formal [3 + 2] annulation reaction of propargyl sulfonium compounds and: N -ylides: Access to pyrrolo[2,1- a] quinolines, pyrrolo[2,1- a] phthalazines and indolizines

A sequential [3 + 2] annulation of prop-2-ynylsulfonium salt and N-ylides was developed, leading to the formation of a series of pyrrolo[2,1-a]quinolines, pyrrolo[2,1-a]phthalazines and indolizines. The protocol featured the simultaneous one-pot formation of three new C-C bonds in moderate yields under mild conditions. In this reaction, the prop-2-ynylsulfonium salts acted as the C2 synthons and sulfide served as the leaving group. The resultant products could serve as useful precursors for the synthesis of diverse chemical compounds. This journal is

CuBr-Catalyzed Aerobic Decarboxylative Cycloaddition for the Synthesis of Indolizines under Solvent-Free Conditions

An efficient synthesis of diversified indolizine derivatives was developed via CuBr-catalyzed reaction of pyridines, methyl ketones and alkenoic acids under solvent-free conditions in oxygen atmosphere. This synthesis involves cascade processes of copper-catalyzed bromination of the methyl ketone, 1,3-dipolar cycloaddition of the pyridinium ylide with the alkenoic acid, followed by oxidative decarboxylation and dehydrogenative aromatization of the primary cycloadduct. By this protocol, a wide range of indoliznes with different substitution patterns were selectively prepared in one pot from simple substrates in good to excellent yields.

Thermal Rearrangements of Cyclic Amine Ylides. VIII. Intramolecular Cyclization of 2-Ethynylpyridine N-Ylides into Indolizines and Cyclazines

Treatment of 6-unsubstituted 2-ethynyl-1-phenacylpyridinium bromides (10a-c) with 1,5-diazabicycloundec-5-ene in refluxing benzene resulted in cyclization to give the 3-benzoyl-indolizines (11) via the N-ylide intermediates 13, whereas heating the