36953-37-4

Basic information

• Product Name: 4-BROMOPYRIDIN-2-OL
• Synonyms: 4-Iodoopyridin-2(1H)-one;4-BROMO-2-PYRIDINOL;4-BROMO-2-HYDROXYPYRIDINE;4-BROMOPYRIDIN-2-OL;4-Iodo-1H-pyridin-2-one;2-HYDROXY-4-BROMOPYRIDINE;4-IODOPYRIDIN-2(1H)-ONE;4-Iodo-1H-pyridin-2-one 97%
• CAS NO: 36953-37-4
• Molecular Formula: C₅H₄BrNO
• Molecular Weight: 174
• Product Categories: Pyridine Series;pharmacetical;Halides;Pyridines;Pyridine;Heterocycle-Pyridine series
• Mol File: 36953-37-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 186 °C
• Boiling Point: 305.9 °C at 760 mmHg
• Flash Point: 138.8 °C
• Appearance: White/Crystalline Powder
• Density: 1.776 g/cm³
• Vapor Pressure: 0.418mmHg at 25°C
• Refractive Index: 1.543
• Storage Temp.: Room temperature.
• PKA: 10.54±0.10(Predicted)
• CAS DataBase Reference: 4-BROMOPYRIDIN-2-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMOPYRIDIN-2-OL(36953-37-4)
• EPA Substance Registry System: 4-BROMOPYRIDIN-2-OL(36953-37-4)

Safety Data

• Statements: 36/38
• Safety Statements: 36
• Hazardous Substances Data: 36953-37-4(Hazardous Substances Data)

Usage

Description

4-BROMOPYRIDIN-2-OL, also known as 4-Bromo-2-hydroxypyridine, is an organic compound with the molecular formula C5H4BrNO. It is a derivative of pyridinol, featuring a bromo substituent at the 4th position and a hydroxyl group at the 2nd position. 4-BROMOPYRIDIN-2-OL is known for its potential applications in the pharmaceutical and chemical industries due to its unique structural properties.

Uses

Used in Pharmaceutical Industry:
4-BROMOPYRIDIN-2-OL is used as a reagent for the synthesis of trans-3,4’-bispyridinylethylenes. These compounds are known to act as inhibitors of protein kinase B (PKB), which plays a crucial role in various cellular processes, including cell survival, growth, and apoptosis. By inhibiting PKB, these compounds can potentially be used in the treatment of cancer, as they may help to prevent the uncontrolled growth and proliferation of cancer cells.
Additionally, 4-BROMOPYRIDIN-2-OL can be utilized in the development of other bioactive molecules and pharmaceutical agents, given its unique structural features and reactivity. Its potential applications in drug discovery and design make it a valuable compound for further research and development in the pharmaceutical industry.

InChI:InChI=1/C6H6BrNO/c1-9-6-4-5(7)2-3-8-6/h2-4H,1H3

Upstream product

• 100367-39-3 4-bromo-2-methoxypyridine 
• 73583-37-6 2-chloro-4-bromopyridine 
• 1214900-01-2 2-(benzyloxy)pyridin-4-amine 
• 960298-00-4 2-(benzyloxy)-4-bromopyridine 
• 14432-12-3 4-Amino-2-chloropyridine 
• 84249-14-9 2-amino-4-bromopyridine 

Downstream Products

• 1001076-61-4 C₂₂H₂₇N₃O₂S 
• 865156-55-4 4-bromo-2-(3-methoxypropoxy)pyridine 
• 889865-56-9 4-bromo-1-(2-hydroxyethyl)pyridin-2(1H)-one 
• 1198803-37-0 2-methyl-N-[6-(2-oxo-1,2-dihydro-4-pyridinyl)-1H-indazol-4-yl]-1,3-thiazole-4-carboxamide 
• 832735-56-5 4-bromo-2-(difluoromethoxy)pyridine 
• 1237534-53-0 2-(4-bromo-pyridin-2-yloxy)-2-methyl-propionic acid methyl ester 
• 1193334-89-2 3-(4-bromo-2-oxo-2H-pyridin-1-yl)-2-methyl-propionic acid methyl ester 
• 1237534-49-4 4-bromo-1-[(S)-tetrahydro-furan-3-yl]-1H-pyridin-2-one 
• 1237534-50-7 4-bromo-2-[(S)-tetrahydro-furan-3-yloxy]-pyridine 
• 1193334-88-1 4-bromo-1-(2-hydroxy-2-methyl-propyl)-1H-pyridin-2-one 
• 1254730-45-4 C₁₄H₁₈BrNO₃ 
• 1263184-47-9 C₁₈H₁₉BrN₂O₂ 
• 960298-00-4 2-(benzyloxy)-4-bromopyridine 
• 1193334-86-9 4-bromo-1-cyclopropylpyridin-2(1H)-one 

Relevant articles and documents

NOVEL COMPOUNDS AS NADPH OXIDASE INHIBITORS

The present invention is related to new compounds, pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).

Concise Entries to 4-Halo-2-pyridones and 3-Bromo-4-halo-2-pyridones

Methods for the synthesis of both simple 4-halo-2-pyridones and more functionalized 3,4-di- and (3,4,5-tri)-halo-2-pyridones are described that are based on a combination of Sandmeyer and regioselective (copper-mediated) halogenation, with a 2-chloro or a 2-benzyloxy moiety serving as a masked 2-pyridone.

Intrinsic electrophilicity of the 4-methylsulfonyl-2-pyridone scaffold in glucokinase activators: Role of glutathione-S-transferases and in vivo quantitation of a glutathione conjugate in rats

Previous studies on the in vitro metabolism of 4-alkylsulfonyl-2-pyridone- based glucokinase activators revealed a facile, non-enzymatic displacement of the 4-alkylsulfonyl group by glutathione. In the present studies, a role for glutathione-S-transferases (GST) as catalysts in the desulfonylation reaction was demonstrated using a combination of human liver microsomes, human liver cytosol and human GSTs. The identification of a glutathione conjugate in circulation following intravenous administration of a candidate 4-methylsulfonyl-2-pyridone to rats confirmed the relevance of the in vitro findings.