36972-82-4Relevant articles and documents
Synthesis of the Coenzyme Metabolite 1,6-Dihydro-6-oxo-1-(β-D-ribofuranosyl)-3-pyridinecarboxamide
Frister, Hermann,Kemper, Klaus,Boos, Karl-Siegfried,Schlimme, Eckhard
, p. 510 - 516 (2007/10/02)
The NAD(P) coenzyme metabolite 1,6-dihydro-6-oxo-1-(β-D-ribofuranosyl)-3-pyridinecarboxamide (9) which is excreted in human urine and its 3-carboxylic acid 8 were synthesized by condensation of silylated 6-oxo-3-pyridinecarboxamide 4 and the corresponding silylated 3-carboxylic acid 2 with 1,2,3,5-tetra-O-acetyl-β-D-ribofuranose in acetonitrile in the presence of tin tetrachloride.The ribosidation site in 8 and 9 was assigned by 1H and 13C NMR spectroscopy.