36978-49-1

Basic information

• Product Name: 3-(P-CHLOROBENZOYL)-BUTYRIC ACID
• Synonyms: CHEMBRDG-BB 5879341;3-(P-CHLOROBENZOYL)-BUTYRIC ACID 98%;3-(p-Chlorobenzoyl)butyric acid,98%;3-(P-CHLOROBENZOYL)-BUTYRIC ACID
• CAS NO: 36978-49-1
• Molecular Formula: C₁₁H₁₁ClO₃
• Molecular Weight: 226.66
• Mol File: 36978-49-1.mol
• Article Data: 15

Chemical Properties

• Melting Point: 124-129 °C
• Boiling Point: 324.6°C (rough estimate)
• Flash Point: 209.7°C
• Appearance: /
• Density: 1.2401 (rough estimate)
• Vapor Pressure: 6.51E-08mmHg at 25°C
• Refractive Index: 1.4530 (estimate)
• CAS DataBase Reference: 3-(P-CHLOROBENZOYL)-BUTYRIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(P-CHLOROBENZOYL)-BUTYRIC ACID(36978-49-1)
• EPA Substance Registry System: 3-(P-CHLOROBENZOYL)-BUTYRIC ACID(36978-49-1)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 36978-49-1(Hazardous Substances Data)

Usage

Chemical Properties

Pink to brown powder

InChI:InChI=1/C11H11ClO3/c12-9-6-4-8(5-7-9)10(13)2-1-3-11(14)15/h4-7H,1-3H2,(H,14,15)

Upstream product

• 108-55-4 glutaric anhydride, 
• 108-90-7 chlorobenzene 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 1129273-72-8 (1S,2R)-2-(4-chlorophenyl)cyclohexanol 
• 40297-26-5 (±)-2-(4-chlorophenyl)cyclopentan-1-one 

Downstream Products

• 371969-19-6 5-bromo-2-(4-chlorophenyl)-1H-indole-3-propanoic acid 
• 290832-34-7 5-chloro-2-(4-chlorophenyl)-1H-indole-3-propanoic acid 
• 290831-57-1 1-{3-[5-Chloro-2-(4-chlorophenyl)-1H-indol-3-yl]-1-oxopropyl}-4-(2-methoxyphenyl)piperazine 
• 71354-29-5 methyl 5-(4-chlorophenyl)-5-oxopentanoate 
• 1242183-73-8 3-(6-(4-chlorophenyl)-4-(pyridin-2-yl)-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)propanoic acid 
• 1242183-67-0 3-(6-(4-chlorophenyl)-4-(furan-2-yl)-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)propanoic acid 
• 1242183-68-1 3-(6-(4-chlorophenyl)-4-(2-hydroxyphenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)propanoic acid 

Relevant articles and documents

Visible Light-Driven, Copper-Catalyzed Aerobic Oxidative Cleavage of Cycloalkanones

A visible light-driven, copper-catalyzed aerobic oxidative cleavage of cycloalkanones has been presented. A variety of cycloalkanones with varying ring sizes and various α-substituents reacted well to give the distal keto acids or dicarboxylic acids with moderate to good yields.

Iridium-Catalyzed Asymmetric Hydrogenation of ?- A nd ?-Ketoacids for Enantioselective Synthesis of ?- A nd ?-Lactones

A highly efficient asymmetric hydrogenation of ?- A nd ?-ketoacids was developed by using a chiral spiro iridium catalyst (S)-1a, affording the optically active ?- A nd ?-hydroxy acids/lactones in high yields with excellent enantioselectivities (up to >99% ee) and turnover numbers (TON up to 100000). This protocol provides an efficient and practical method for enantioselective synthesis of Ezetimibe.

Cooperative iodine and photoredox catalysis for direct oxidative lactonization of carboxylic acids

A new method for the formation of γ- and δ-lactones from carboxylic acids through direct conversion of benzylic C-H to C-O bonds is described. The reaction is conveniently induced by visible light and relies on a mild cooperative catalysis by the combination of molecular iodine and an organic dye.