36982-56-6

Basic information

• Product Name: 2-Cyclopropylethyl bromide
• Synonyms: (2-Bromoethyl)cyclopropane;2-Cyclopropylethyl bromide
• CAS NO: 36982-56-6
• Molecular Formula: C₅H₉Br
• Molecular Weight: 149.02896
• Mol File: 36982-56-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 129℃
• Flash Point: 39.2±13.6℃
• Appearance: /
• Density: 1.433±0.06 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• CAS DataBase Reference: 2-Cyclopropylethyl bromide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Cyclopropylethyl bromide(36982-56-6)
• EPA Substance Registry System: 2-Cyclopropylethyl bromide(36982-56-6)

Safety Data

• Hazardous Substances Data: 36982-56-6(Hazardous Substances Data)

Usage

Description

2-Cyclopropylethyl bromide, also known as 2-bromoethylcyclopropane, is an organic compound that serves as a versatile reagent in the synthesis of various pharmaceutical compounds. It is characterized by its unique cyclopropane ring and bromoethyl group, which contribute to its reactivity and potential applications in the chemical and pharmaceutical industries.

Uses

Used in Pharmaceutical Industry:
2-Cyclopropylethyl bromide is used as a synthetic reagent for the production of 22-Hydroxycholesterol (H918010) derivatives. These derivatives are known to act as serum cholesterol-lowering agents, making them valuable in the development of treatments for hypercholesterolemia and related cardiovascular conditions.
Additionally, 2-Cyclopropylethyl bromide is used in the preparation of pyridazinones, which are compounds that act as cyclooxygenase 2-inhibitors. These inhibitors possess anti-inflammatory and antiangiogenic effects, making them potential candidates for the development of drugs to treat inflammation and angiogenesis-related diseases, such as arthritis and cancer.

Upstream product

• 861787-21-5 N-(2-cyclopropyl-ethyl)-benzamide 
• 2566-44-1 1-cyclopropylethanol 
• 6542-60-5 2-cyclopropylacetonitrile 
• 62893-54-3 2-(cyclopropyl)ethylamine 
• 5239-82-7 cyclopropylacetic acid 
• 14902-14-8 -triphenyl-phosphoran 
• 34108-21-9 methyl cyclopropylacetate 

Downstream Products

• 5618-03-1 3-cyclopropanepropionic acid 
• 51598-34-6 9ξ-(2-cyclopropyl-ethyl)-7t-((S)-3-hydroxy-2-phenyl-propionyloxy)-9ξ-methyl-(1rN,2tH,4tH,5cN)-3-oxa-9-aza-tricyclo[3.3.1.0^2,4]nonanium; bromide 
• 78945-53-6 4-(2-Cyclopropyl-ethyl)-1,2-diphenyl-pyrazolidine-3,5-dione 
• 1040542-24-2 ethyl 2-(2-cyclopropylethyl)-5-hydroxy-3-oxo-6-phenyl-2,3-dihydro-4-pyridazinecarboxylate 
• 1092533-01-1 4-(2-cyclopropylethoxy)-4-(4-fluorophenyl)-1-phenylcyclohexanecarbonitrile 
• 1445848-01-0 potassium 2-cyclopropyl-ethyl-trifluoroborate 
• 94361-06-5 cyproconazol 

Relevant articles and documents

SYNTHESIS AND STRUCTURE OF cis-PtX2(P(t-Bu)2CH2CH2CH=CHCH3) (X = Cl, Br), A PLATINUM ?-OLEFIN COMPLEX FORMED BY THE INTRAMOLECULAR ACTIVATION OF A CYCLOPROPYLPHOSPHINE

The mixed chloro/bromo ?-olefin complexes cis-PtX2(P(t-Bu)2CH2CH2CH=CHCH3) (2) have been prepared by the reaction of Zeise's salt (K) with in boiling ethanol.The dimer complexes (1) (X, Y = Cl or Br) form first with subsequent activation of cyclopropane to give the monomeric ?-olefin complexes (2).The mixed ?-olefin complexes 2 co-crystallize.The average structure of 2 has been determined by X-ray methods.The relative occupancies in bromine for halogen sites cis- and trans- to coordinated olefin are 0.464(6) and 0.256(6), respectively.The olefin is symmetrically bound to the Pt atom (Pt-C 2.17(1) Angstroem).The olefinic C-C bond length is 1.38(1) Angstroem.

Pyrazolo[3,4-b]pyridine carboxylic acid esters and their pharmaceutical use

Compounds of the formula (I): STR1 wherein R1, R3, R4, R5 and R6 have defined values and the N-oxides at the 7-position of the pyrazolo[3,4-b]pyridine ring system and the pharmaceutically-acceptable acid-addition salts thereof, processes for their preparation and use, pharmaceutical compositions, and intermediates for preparing said compounds of the formula (I). The compounds of formula (I) are central nervous system depressants, for example anxiolytic agents.

24-Cyclopropylcholene-3β, 22-diols and esters thereof

24-Cyclopropylcholene-3β, 22-diols and esters thereof which control serum cholesterol levels and their preparation are disclosed.