370-09-2

Basic information

• Product Name: N-(3-pyridylmethyl)pyrrolidine
• Synonyms: N-(3-pyridylmethyl)pyrrolidine
• CAS NO: 370-09-2
• Molecular Formula: C10H14 N2
• Molecular Weight: 162.23
• Mol File: 370-09-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 249.9°Cat760mmHg
• Flash Point: 104.9°C
• Appearance: /
• Density: 1.072g/cm³
• Vapor Pressure: 0.0224mmHg at 25°C
• Refractive Index: 1.564
• CAS DataBase Reference: N-(3-pyridylmethyl)pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-pyridylmethyl)pyrrolidine(370-09-2)
• EPA Substance Registry System: N-(3-pyridylmethyl)pyrrolidine(370-09-2)

Safety Data

• Hazardous Substances Data: 370-09-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H14N2/c1-2-7-12(6-1)9-10-4-3-5-11-8-10/h3-5,8H,1-2,6-7,9H2

Upstream product

• 77727-88-9 (pyridin-3-yl)(pyrrolidin-1-yl)methanone 
• 3731-52-0 3-Aminomethylpyridine 
• 110-63-4 Butane-1,4-diol 
• 59-67-6 nicotinic acid 
• 123-75-1 pyrrolidine 
• 500-22-1 3-pyridinecarboxaldehyde 
• 100-55-0 3-hydroxymethylpyridin 
• 609-36-9 rac-Pro-OH 
• 6959-48-4 3-chloromethylpyridinium chloride 

Relevant articles and documents

Ruthenium and Iron-Catalysed Decarboxylative N-alkylation of Cyclic Α-Amino Acids with Alcohols: Sustainable Routes to Pyrrolidine and Piperidine Derivatives

A modular and waste-free strategy for constructing N-substituted cyclic amines via decarboxylative N-alkylation of α-amino acids employing ruthenium- and iron-based catalysts is presented. The reported method allows the synthesis of a wide range of five- and six-membered N-alkylated heterocycles in moderate-to-excellent yields starting from predominantly proline and a broad range of benzyl alcohols, and primary and secondary aliphatic alcohols. Examples using pipecolic acid for the construction of piperidine derivatives, as well as the one-pot synthesis of α-amino nitriles, are also shown.

Iridium-catalyzed decarboxylative N-alkylation of α-amino acids with primary alcohols

A new decarboxylative N-alkylation reaction of α-amino acids has been developed. A variety of tertiary amines were obtained in good to excellent yields via the decarboxylative N-alkylation reaction of α-amino acids with primary alcohols catalyzed by a CpIr complex. Georg Thieme Verlag Stuttgart New York.

An efficient synthesis of nitrogen heterocycles by Cp*Ir-catalyzed N-cycloalkylation of primary amines with diols

A new efficient method for the N-cycloalkylation of primary amines with diols catalyzed by a Cp*Ir complex have been developed. A variety of five-, six-, and seven-membered cyclic amines are synthesized in good to excellent yields in environmentally benign and atom economical manner with the formation of only water as a coproduct. A large scale synthesis of N-benzylpiperidine and a two-step asymmetric synthesis of (S)-2-phenylpiperidine using (R)-1-phenylethylamine as a starting primary amine have been also achieved.