37010-53-0

Basic information

• Product Name: 1-(2,3-DICHLOROPHENYL)-2,5-DIHYDRO-1H-PYRROLE-2,5-DIONE
• Synonyms: 1-(2,3-DICHLORPHENYL)-1H-PYRROLE-2,5-DIONE;1-(2,3-DICHLOROPHENYL)-1H-PYRROLE-2,5-DIONE;1-(2,3-DICHLOROPHENYL)-2,5-DIHYDRO-1H-PYRROLE-2,5-DIONE;AKOS MSC-0060;AKOS B001456;ASISCHEM C66340;ART-CHEM-BB B001456;1-(2,3-dichlorophenyl)-3-pyrroline-2,5-quinone
• CAS NO: 37010-53-0
• Molecular Formula: C₁₀H₅Cl₂NO₂
• Molecular Weight: 242.06
• Mol File: 37010-53-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 379.4°Cat760mmHg
• Flash Point: 183.2°C
• Appearance: /
• Density: 1.57g/cm³
• Vapor Pressure: 5.89E-06mmHg at 25°C
• Refractive Index: 1.648
• PKA: -2.87±0.20(Predicted)
• CAS DataBase Reference: 1-(2,3-DICHLOROPHENYL)-2,5-DIHYDRO-1H-PYRROLE-2,5-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,3-DICHLOROPHENYL)-2,5-DIHYDRO-1H-PYRROLE-2,5-DIONE(37010-53-0)
• EPA Substance Registry System: 1-(2,3-DICHLOROPHENYL)-2,5-DIHYDRO-1H-PYRROLE-2,5-DIONE(37010-53-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 37010-53-0(Hazardous Substances Data)

Usage

General Description

1-(2,3-Dichlorophenyl)-2,5-dihydro-1H-pyrrole-2,5-dione is a chemical compound that is commonly used in the synthesis of pharmaceuticals and agrochemicals. It is a heterocyclic compound with a pyrrole-2,5-dione core and two chlorine atoms attached to the phenyl group. 1-(2,3-DICHLOROPHENYL)-2,5-DIHYDRO-1H-PYRROLE-2,5-DIONE has been found to exhibit various biological activities, including potential anti-fungal and anti-cancer properties. Its unique structure and reactivity make it a valuable intermediate in the production of a wide range of chemical products and pharmaceuticals. However, proper handling and storage procedures should be followed due to its potential hazards and toxicity.

InChI:InChI=1/C10H5Cl2NO2/c11-6-2-1-3-7(10(6)12)13-8(14)4-5-9(13)15/h1-5H

Upstream product

• 608-27-5 2,3-dichloroaniline 
• 306935-73-9 C₁₀H₇Cl₂NO₃ 
• 108-31-6 maleic anhydride 

Downstream Products

• 307527-74-8 3-chloro-1-(2,3-dichlorophenyl)-4-morpholino-1H-pyrrole-2,5-dione 

Relevant articles and documents

Potent Nematicidal Activity of Maleimide Derivatives on Meloidogyne incognita

Different maleimide derivatives were synthesized and assayed for their in vitro activity on the soil inhabiting, plant-parasitic nematode Meloidogyne incognita, also known as root-knot nematode. The compounds maleimide, N-ethylmaleimide, N-isopropylmaleimide, and N-isobutylmaleimide showed the strongest nematicidal activity on the second stage juveniles of the root-knot nematode with EC50/72h values of 2.6 ± 1.3, 5.1 ± 3.4, 16.2 ± 5.4, and 19.0 ± 9.0 mg/L, respectively. We also determined the nematicidal activity of copper sulfate, finding an EC50 value of 48.6 ± 29.8 mg/L. When maleimide at 1 mg/L was tested in combination with copper sulfate at 50 mg/L, we observed 100% mortality of the nematodes. We performed a GC-MS metabolomics analysis after treating nematodes with maleimide at 8 mg/L for 24 h. This analysis revealed altered fatty acids and diglyceride metabolites such as oleic acid, palmitic acid, and 1-monopalmitin. Our results suggest that maleimide may be used as a new interesting building block for developing new nematicides in combination with copper salts.

An optimized RAD51 inhibitor that disrupts homologous recombination without requiring michael acceptor reactivity

Homologous recombination (HR) is an essential process in cells that provides repair of DNA double-strand breaks and lesions that block DNA replication. RAD51 is an evolutionarily conserved protein that is central to HR. Overexpression of RAD51 protein is