37033-95-7 Usage
Description
ETHYL 5-BENZYLOXYINDOLE-2-CARBOXYLATE is an organic compound with the molecular formula C21H19NO4. It is a derivative of indole, a heterocyclic aromatic organic compound, and is characterized by the presence of a benzyloxy group and a carboxylate group. ETHYL 5-BENZYLOXYINDOLE-2-CARBOXYLATE is known for its potential applications in various fields, particularly in the pharmaceutical and chemical industries, due to its unique structural properties and reactivity.
Uses
Used in Pharmaceutical Industry:
ETHYL 5-BENZYLOXYINDOLE-2-CARBOXYLATE is used as a reactant for the preparation of indolyl ethanones, which serve as indoleamine 2,3-dioxygenase inhibitors. These inhibitors play a crucial role in modulating the activity of the enzyme indoleamine 2,3-dioxygenase, which is involved in the metabolism of tryptophan and has been linked to various physiological and pathological processes.
ETHYL 5-BENZYLOXYINDOLE-2-CARBOXYLATE is also used as a reactant for the preparation of histamine H3 receptor inverse agonists. These compounds have the potential to modulate the activity of histamine H3 receptors, which are involved in various physiological processes, including the regulation of wakefulness, appetite, and cognitive function. Inverse agonists of the histamine H3 receptor may have therapeutic applications in the treatment of conditions such as insomnia, obesity, and cognitive disorders.
In addition, ETHYL 5-BENZYLOXYINDOLE-2-CARBOXYLATE is used as a reactant for the preparation of PPAR-γ binding agents. These agents have the potential to modulate the activity of the peroxisome proliferator-activated receptor gamma (PPAR-γ), a nuclear receptor that plays a key role in the regulation of lipid metabolism and glucose homeostasis. PPAR-γ binding agents may have applications in the treatment of metabolic disorders, such as type 2 diabetes and obesity, as well as in the development of therapies for osteoporosis.
Furthermore, ETHYL 5-BENZYLOXYINDOLE-2-CARBOXYLATE is used as a reactant for the preparation of nonpeptide glycoprotein IIB/IIIA inhibitors. These inhibitors target the glycoprotein IIB/IIIA receptor, which is involved in platelet aggregation and blood clot formation. Nonpeptide glycoprotein IIB/IIIA inhibitors may have therapeutic applications in the prevention and treatment of thrombotic disorders, such as acute coronary syndrome and stroke.
Used in Chemical Industry:
In the chemical industry, ETHYL 5-BENZYLOXYINDOLE-2-CARBOXYLATE may be used as an intermediate or building block in the synthesis of various complex organic compounds, particularly those with potential applications in the pharmaceutical, agrochemical, and materials science sectors. Its unique structural features and reactivity make it a valuable component in the development of novel molecules with diverse biological activities and properties.
Check Digit Verification of cas no
The CAS Registry Mumber 37033-95-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,7,0,3 and 3 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 37033-95:
(7*3)+(6*7)+(5*0)+(4*3)+(3*3)+(2*9)+(1*5)=107
107 % 10 = 7
So 37033-95-7 is a valid CAS Registry Number.
InChI:InChI=1/C18H17NO3/c1-2-21-18(20)17-11-14-10-15(8-9-16(14)19-17)22-12-13-6-4-3-5-7-13/h3-11,19H,2,12H2,1H3
37033-95-7Relevant articles and documents
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Boehme
, p. 2502 (1953)
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Synthesis method of indole-2-carboxylic acid and derivative thereof
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Paragraph 0031-0038, (2019/02/21)
The invention relates to a synthesis method of indole-2-carboxylic acid and a derivative thereof, belonging to the field of organic synthesis. In the synthesis method, the indole-2-carboxylic acid isprepared through two steps of reaction with phenylhydrazine hydrochloride and ethyl pyruvate as raw materials and sulfuric acid as a catalyst. The synthesis method has a short process and uses fewer raw materials, the total yield of indole-2-carboxylic acid reaches 70% or above. The method can synthesize both indole-2-carboxylic acid and the derivative thereof, thereby being suitable for industrial production.
Complementary asymmetric routes to (R)-2-(7-hydroxy-2,3-dihydro-1 H-pyrrolo[1,2-a]indol-1-yl)acetate
Schrader, Thomas O.,Johnson, Benjamin R.,Lopez, Luis,Kasem, Michelle,Gharbaoui, Tawfik,Sengupta, Dipanjan,Buzard, Daniel,Basmadjian, Christine,Jones, Robert M.
supporting information, p. 6306 - 6309 (2013/02/25)
Two distinct and scalable enantioselective approaches to the tricyclic indole (R)-2-(7-hydroxy-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate, an important synthon for a preclinical S1P1 receptor agonist, are reported. Route 1 employs a modified version of Smith's modular 2-substituted indole synthesis as the key transformation. Route 2 involves a highly enantioselective CuH-catalyzed 1,4-hydrosilylation as the stereodefining step. Both routes can be performed without chromatography to provide multigram quantities of the tricycle in ≥98% ee.
