3704-01-6 Usage
Description
4-Desacetyl Vincristine is a metabolite of Vincristine, a naturally occurring alkaloid with potent anti-cancer properties. It is found in bile and is characterized by its white to off-white solid appearance. 4-Desacetyl Vincristine has demonstrated significant antitumor activity, particularly against human colon carcinoma.
Uses
Used in Anticancer Applications:
4-Desacetyl Vincristine is used as an antineoplastic agent for the treatment of human colon carcinoma. It exhibits its therapeutic effects by targeting and disrupting the microtubules within cancer cells, thereby inhibiting cell division and growth.
Used in Pharmaceutical Industry:
4-Desacetyl Vincristine is used as an active pharmaceutical ingredient for the development of cancer therapeutics. Its role in this industry is to provide a potent and targeted approach to treating colon carcinoma, offering a valuable alternative or adjunct to existing treatment options.
Used in Research and Development:
In the field of biomedical research, 4-Desacetyl Vincristine is used as a key compound for studying the mechanisms of action and potential applications in cancer treatment. Its study contributes to the broader understanding of microtubule-targeting agents and their role in combating cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 3704-01-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,7,0 and 4 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 3704-01:
(6*3)+(5*7)+(4*0)+(3*4)+(2*0)+(1*1)=66
66 % 10 = 6
So 3704-01-6 is a valid CAS Registry Number.
3704-01-6Relevant articles and documents
Folate-vinca alkaloid conjugates for cancer therapy: A structure-activity relationship
Leamon, Christopher P.,Vlahov, Iontcho R.,Reddy, Joseph A.,Vetzel, Marilynn,Santhapuram, Hari Krishna R.,You, Fei,Bloomfield, Alicia,Dorton, Ryan,Nelson, Melissa,Kleindl, Paul,Vaughn, Jeremy F.,Westrick, Elaine
, p. 560 - 568 (2014/04/03)
Vintafolide is a potent folate-targeted vinca alkaloid small molecule drug conjugate (SMDC) that has shown promising results in multiple clinical oncology studies. Structurally, vintafolide consists of 4 essential modules: (1) folic acid, (2) a hydrophili
