37051-66-4Relevant articles and documents
A versatile approach to planar chiral monophosphane ligands
Gibson, Susan E.,Rendell, Jacob T.,Rudd, Matthew
, p. 3631 - 3638 (2006)
The enantioselective reaction of a chiral bisamide and an electrophile with benzyl ether complexes of arene tricarbonyl chromium(0) was used to introduce the asymmetry into a synthesis of novel enantiopure planar chiral ligands. Elaboration of the resulting ether complexes [η6-4-t-BuC 6H4CHE1(OR)]Cr(CO)3 via a diastereo-selective ortholithiation/chlorophosphane quench protocol led to the synthesis of planar chiral monophosphane complexes with high enantiomeric purity (typically 96-98% ee) for assessment in the palladium-catalyzed asymmetric hydrosilylation of styrene. The identity of benzylic substituent E1 (installed using the chiral base reaction) was found to have a significant effect on the enantioselectivity of resulting catalysts. Removal of the tricarbonylchromium(0) unit from the structurally optimized phosphane ligand was accomplished using a high-yielding borane protection-aerial oxidation-deprotection strategy. Georg Thieme Verlag Stuttgart.
