37076-47-4

Basic information

• Product Name: Acetic acid, (triphenylmethoxy)-
• CAS NO: 37076-47-4
• Molecular Formula: C21H18O3
• Molecular Weight: 318.372
• Mol File: 37076-47-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Acetic acid, (triphenylmethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, (triphenylmethoxy)-(37076-47-4)
• EPA Substance Registry System: Acetic acid, (triphenylmethoxy)-(37076-47-4)

Safety Data

• Hazardous Substances Data: 37076-47-4(Hazardous Substances Data)

Upstream product

• 79-14-1 glycolic Acid 
• 76-83-5 trityl chloride 
• 96-35-5 glycolic acid methyl ester 
• 58352-78-6 ethyl 2-(trityloxy)acetate 

Downstream Products

• 58352-80-0 Trityloxy-acetic acid 8-hydroxy-9,10-dioxo-9,10-dihydro-anthracen-1-yl ester 
• 1428847-72-6 (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(trityloxy)acetoxy)ethyl)pyridine 1-oxide 
• 1275616-91-5 ethyl (2-trityloxyacetylamino)acetate 
• 1275616-92-6 (2-trityloxyacetylamino)acetic acid 
• 851181-07-2 3-(4-ethyl-phenyl)-5-trityloxymethyl-[1,2,4]oxadiazole 

Relevant articles and documents

Activation of lysine-specific demethylase 1 inhibitor peptide by redox-controlled cleavage of a traceless linker

We have previously employed cyclization of a linear peptide as a strategy to modulate peptide function and properties, but cleavage to regenerate the linear peptide left parts of the linker structure on the peptide, interfering with its activity. Here, we focused on cyclization of a linear peptide via a “traceless” disulfide-based linkage that would be cleaved and completely removed in a reducing environment, regenerating the original linear peptide without any linker-related structure. Thus, the linker would serve as a redox switch that would be activated in the intracellular environment. We applied this strategy to a lysine-specific demethylase 1 (LSD1) inhibitor peptide 1. The resulting cyclic peptide 2 exhibited approximately 20 times weaker LSD1-inhibitory activity than peptide 1. Upon addition of reducing reagent, the linker was completely removed to regenerate the linear peptide 1, with full restoration of the LSD1-inhibitory activity. In addition, the cyclic peptide was far less susceptible to proteolysis than the linear counterpart. Thus, this switch design not only enables control of functional activity, but also improves stability. This approach should be applicable to a wide range of peptides, and may be useful in the development of peptide pharmaceuticals.

Improved solid phase synthesis of peptide carboxyamidomethyl (Cam) esters for enzymatic segment condensation

Peptide C-terminal carboxyamidomethyl (Cam-)esters are pivotal building blocks for enzymatic segment condensation and their yield and purity are crucial for the overall efficiency of this strategy. Although a few methods for their preparation have been di

DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS

The invention relates to inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to compounds that are derivatives of 1-phenyl-2-pyridinyl alkyl alcohols, methods of preparing such compounds, compositions containing them and therapeutic use thereof.