37076-64-5 Usage
Description
1-(2,3-dihydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione, commonly known as raltitrexed, is a chemical compound belonging to the class of pyrimidines. It features a furan ring and a fluorine atom attached to the pyrimidine ring, which contributes to its potent inhibitory activity against thymidylate synthase, an enzyme crucial for the de novo synthesis of thymidylate, a precursor for DNA replication.
Uses
Used in Pharmaceutical Industry:
1-(2,3-dihydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione is used as an antineoplastic agent for the treatment of various types of cancer, including colorectal, gastric, and pancreatic cancers. Its application is based on its ability to disrupt DNA synthesis and inhibit the proliferation of cancer cells, thereby hindering tumor growth and progression.
Additionally, raltitrexed is marketed under the trade name Tomudex, indicating its commercial availability and established use in the pharmaceutical industry for cancer treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 37076-64-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,7,0,7 and 6 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 37076-64:
(7*3)+(6*7)+(5*0)+(4*7)+(3*6)+(2*6)+(1*4)=125
125 % 10 = 5
So 37076-64-5 is a valid CAS Registry Number.
37076-64-5Relevant articles and documents
Synthesis, anti-HIV activity, and resistance profiles of ribose modified nucleoside phosphonates
Mackman, Richard L.,Boojamra, Constantine G.,Prasad, Vidya,Zhang, Lijun,Lin, Kuei-Ying,Petrakovsky, Oleg,Babusis, Darius,Chen, James,Douglas, Janet,Grant, Deborah,Hui, Hon C.,Kim, Choung U.,Markevitch, David Y.,Vela, Jennifer,Ray, Adrian,Cihlar, Tomas
, p. 6785 - 6789 (2008/09/18)
A series of nucleoside phosphonate reverse transcriptase (RT) inhibitors have been synthesized and their anti-HIV activity and resistance profiles evaluated. The most potent analog [5-(6-amino-purin-9-yl)-2,5-dihydro-furan-2-yloxymethyl]-phosphonic acid (d4AP) demonstrated a HIV EC50 = 2.1 μM, and the most favorable resistance profile against HIV-1 variants with K65R, M184V or multiple thymidine analog mutations in RT.
