370880-82-3

Basic information

• Product Name: N-Boc-6-azaindole
• Synonyms: N-Boc-6-azaindole;1H-pyrrolo[2,3-c]pyridine-1-carboxylate;tert-Butyl 1H-pyrrolo[2,3-c]pyridine-1-carboxylate
• CAS NO: 370880-82-3
• Molecular Formula: C₁₂H₁₄N₂O₂
• Molecular Weight: 218
• Mol File: 370880-82-3.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-Boc-6-azaindole(CAS DataBase Reference)
• NIST Chemistry Reference: N-Boc-6-azaindole(370880-82-3)
• EPA Substance Registry System: N-Boc-6-azaindole(370880-82-3)

Safety Data

• Hazardous Substances Data: 370880-82-3(Hazardous Substances Data)

Usage

Description

N-Boc-6-azaindole, with the molecular formula C15H15NO2, is a versatile chemical compound belonging to the indole family. It features a six-membered heterocyclic ring with a nitrogen atom, and the N-Boc (tert-butoxycarbonyl) group attached to the nitrogen atom serves to protect the reactive site and control the molecule's reactivity. N-Boc-6-azaindole is widely recognized for its utility in organic synthesis and medicinal chemistry, particularly in the development of pharmaceuticals and agrochemicals.

Uses

Used in Organic Synthesis:
N-Boc-6-azaindole is used as a building block in organic synthesis for its ability to facilitate the creation of complex molecular structures. The N-Boc group enhances the stability and reactivity control of the molecule, making it a valuable component in the synthesis of various organic compounds.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, N-Boc-6-azaindole is utilized as a precursor to biologically active compounds. Its protective N-Boc group allows for the development of pharmaceuticals with specific therapeutic properties, contributing to drug discovery and the advancement of novel treatments.
Used in Pharmaceutical Development:
N-Boc-6-azaindole is employed as a key intermediate in the synthesis of pharmaceuticals. Its role in creating diverse drug candidates highlights its importance in the development of new medications with potential therapeutic applications.
Used in Agrochemical Development:
Similarly, in agrochemical development, N-Boc-6-azaindole serves as a crucial building block for the creation of agrochemicals. Its versatility and protective N-Boc group make it suitable for the synthesis of compounds used in agriculture to improve crop protection and yield.
Overall, N-Boc-6-azaindole's applications span across various scientific and industrial fields, underpinning its significance in the creation and development of new chemical entities with practical utility.

Upstream product

• 271-29-4 6-azaindole 
• 24424-99-5 di-tert-butyl dicarbonate 
• 124-63-0 methanesulfonyl chloride 
• 185139-01-9 tert-butyl 2-hydroxy-2,3-dihydro-1H-pyrrolo[2,3-c]pyridine-1-carboxylate 
• 34619-03-9 tert-butyldicarbonate 
• 1346809-07-1 tert-butyl oxazol-5-ylcarbamate 

Downstream Products

• 169750-88-3 tert-butyl 2,3,3a,4,5,6,7,7a-octahydropyrrolo[2,3-c]pyridine-1-carboxylate 
• 1174038-67-5 tert-butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo [2,3-c]pyridine-1-carboxylate 
• 1374243-44-3 tert-butyl 6-(2-(3,5-dichlorophenylamino)acetyl)octahydro-1H-pyrrolo[2,3-c]pyridine-1-carboxylate 
• 1374243-70-5 C₁₅H₁₉Cl₂N₃O 
• 1374239-82-3 2-(3,5-dichlorophenylamino)-1-[1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-octahydro-1H-pyrrolo[2,3-c]pyridin-6-yl]ethanone 
• 1374239-83-4 1-(1-(1H-pyrazolo[3,4-d]pyrimidin-4-yl)tetrahydro-1H-pyrrolo[2,3-c]pyridine-6(2H,7H,7aH)-yl)-2-(3,5-dichlorophenylamino)ethanone 
• 1374243-45-4 C₂₆H₃₅Cl₂N₇O₂Si 
• 1374240-00-2 1-((3aS,7aS)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)tetrahydro-1H-pyrrolo[2,3-c]pyridine-6(2H,7H,7aH)-yl)-2-(3,5-dichlorophenylamino)ethanone 
• 1374240-01-3 1-((3aR,7aR)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)tetrahydro-1H-pyrrolo[2,3-c]pyridine-6(2H,7H,7aH)-yl)-2-(3,5-dichlorophenylamino)ethanone 
• 1438081-00-5 tert-butyl 6-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)octahydro-1H-pyrrolo[2,3-c] pyridine-1-carboxylate 
• 1438072-77-5 N-(3-chloro-4-fluorophenyl)-6-(3-(hexahydro-1H-pyrrolo[2,3-c]pyridin-6(2H)-yl)propoxy)-7-methoxyquinazolin-4-amine 
• 1438072-83-3 N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(1-methylhexahydro-1H-pyrrolo[2,3-c]pyridin-6(2H)-yl)propoxy)quinazolin-4-amine 
• 949559-11-9 (3aS,7aR)-tert-butyl octahydro-1H-pyrrolo[2,3-c]pyridine-1-carboxylate 
• 949559-11-9 (3aR,7aS)-tert-butyl octahydro-1H-pyrrolo[2,3-c]pyridine-1-carboxylate 

Relevant articles and documents

QUINAZOLINE COMPOUNDS, PREPARATION METHODS AND USES THEREOF

Provided herein are novel compounds, for example, compounds having a Formula (I), Formula (II), or Formula (III), or a pharmaceutically acceptable salt thereof. Also provided herein are methods of preparing the compounds and methods of using the compounds, for example, in inhibiting KRAS G12D in a cancer cell, and/or in treating various cancer such as pancreatic cancer, colorectal cancer, lung cancer or endometrial cancer.

HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES

Provided herein are Heterocyclic compounds of formula (I): and pharmaceutically acceptable salts, tautomers, isotopologues, or stereoisomers thereof, wherein W, X, Y, R1, R2, and RN are as defined herein, compositions comprising an effective amount of a Heterocyclic Compound, and methods for treating or preventing animal and human filarial worm infections and diseases.

PYRROLO[2,3-B]PYRIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER

The present application relates to a compound of Formula I, or a salt, hydrate or solvate thereof, as defined herein. The present compounds are found to have pharmacological effects, particularly at MRCK. Further provided are pharmaceutical compositions comprising said compounds. The present invention also relates to the use of these compounds as therapeutic agents, in particular, for the treatment and/or prevention of proliferative diseases, such as cancer.